Volume 10, Issue 3 (2019)
JMBS 2019, 10(3): 343-349 |
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Ramezani B, Alamzadeh I, Vossoughi M, Hajiabbas M. Fabrication of Alginate-Gelatin Hydrogel with Quercus Brantii Galls (Oak) and Silver-Nanoparticles as a Burn Wound Dressing. JMBS 2019; 10 (3) :343-349
URL: http://biot.modares.ac.ir/article-22-16377-en.html
URL: http://biot.modares.ac.ir/article-22-16377-en.html
1- Chemical Engineering Department, Chemical & Petroleum Engineering Faculty, Sharif University of Technology, Tehran, Iran
2- Chemical Engineering Department, Chemical & Petroleum Engineering Faculty, Sharif University of Technology, Tehran, Iran, Biochemical & Bioenvironmental Research Center, Sharif University of Technology, Azadi Street, Tehran, Iran. , alemzadeh@sharif.edu.ac.ir
3- Biotechnology Department, Chemical & Petroleum Engineering Faculty, Sharif University of Technology, Tehran, Iran
2- Chemical Engineering Department, Chemical & Petroleum Engineering Faculty, Sharif University of Technology, Tehran, Iran, Biochemical & Bioenvironmental Research Center, Sharif University of Technology, Azadi Street, Tehran, Iran. , alemzadeh@sharif.edu.ac.ir
3- Biotechnology Department, Chemical & Petroleum Engineering Faculty, Sharif University of Technology, Tehran, Iran
Abstract: (8041 Views)
Burns are one of the most important accidents related to human health. Receiving proper treatment is very important due to the intense complications associated with them. The improvement and elimination of ulcer effect can be achieved by controlling the wound infection. According to this, wound dressing containing antibiotics is one of the effective methods in wound's infection treatment. The use of silver in burns caring has been considered a long time ago, but silver deposits on the liver that causes some problems which can be overcome with the help of nanotechnology. In this study, Silver-Oak nanoparticles were green synthesized by using the ethanol extraction of Iranian Oak with the help of reducing agent. Nanoparticles formation were followed by UV-Visible spectrum and they characterize with SEM images and XRD spectrum. Then Gelatin-Alginate Hydrogel was prepared as a wound dressing and their properties were investigated by the presence of nanoparticles, oak extraction and without any additives. Nanoparticles' diameter is about 30-65nm which are dispersed in the hydrogel with regular pore size about 30-100μm. Oak extraction increase the hydrogel water uptake that improve the wound hilling. Antibacterial properties of wound dressing against Staphylococcus aurous and pseudomonas are investigated by inhibiting zone.
Keywords: Burn Wound Dressing, Silver Nanoparticles, Alginate-Gelatin Hydrogel, Quercus Brantii Galls Extarction
Article Type: Research Paper |
Subject:
Agricultural Biotechnology
Received: 2018/02/4 | Accepted: 2018/03/2 | Published: 2019/09/21
Received: 2018/02/4 | Accepted: 2018/03/2 | Published: 2019/09/21
References
1. Charernsriwilaiwat N, Rojanarata T, Ngawhirunpat T, Sukma M, Opanasopit P. Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts. Int J Pharm. 2013;452(1-2):333-43. [Link] [DOI:10.1016/j.ijpharm.2013.05.012]
2. Gee AO, Baker B,M Silverstein AM, Montero G, Esterhai JL, Mauck RL. Fabrication and evaluation of biomimetic-synthetic nanofibrous composites for soft tissue regeneration. Cell Tissue Res. 2012;347(3):803-13. [Link] [DOI:10.1007/s00441-011-1308-1]
3. Koehler J, Brandl FP, Goepferich AM. Hydrogel wound dressings for bioactive treatment of acute and chronic wounds. Europ Polym J. 2018;100:1-11. [Link] [DOI:10.1016/j.eurpolymj.2017.12.046]
4. Veis A. The macromolecular chemistry of gelatin. New York: Academic Press; 1964. [Link]
5. Djabourov M, Leblond J, Papon P. Gelation of aqueous gelatin solutions .1. Structural investigation. J Phys. 1988;49(2):319-32. [Link] [DOI:10.1051/jphys:01988004902031900]
6. Gelatin Manufacturers Institute of America. Gelatin handbook. Woburn, Massachusetts: Atlantic Gelatin/Kraft Foods Global Inc.; 2012. [Link]
7. Shafaei K, Nahaei MR, Kalhori S, Norani Z, Hosseini M. Determination of prevalent bacteria in burn infections compared to patients' environmental bacteria in burn ward of Shahid Zareh Hospital in Sari, Iran. Med J Tabriz Univ Med Sci Health Serv. 2014;36(4):62-71. [Persian] [Link]
8. Mamani M, Derakhshanfar A, Niayesh A, Hashemi SH, yousefi Mashoof R, Zavar S. Frequency of bacterial burn wounds infection and antimicrobial resistance in burn center of Bessat Hospital of Hamedan. Iran J Surg. 2009;17(1):1-8. [Persian] [Link]
9. Korbekandi H, Chitsazi MR, Asghari G, Bahri Najafi R, Badii A, Iravani S. Green biosynthesis of silver nanoparticles using Quercus brantii (oak) leaves hydroalcoholic extract. Pharm Biol. 2015;53(6):807-12. [Link] [DOI:10.3109/13880209.2014.942868]
10. Jaimand K. Essentional oils, distillations apparatuses, test methods of essential oils and retention indices in essentional oil analysis. 1st Edition. Tehran: Iranian Association of Medicinal Plants; 2006. [Persian] [Link]
11. Arunachalam KD, Annamalai SK, Arunachalam AM, Kennedy S. Green synthesis of crystalline silver nanoparticles using indigofera aspalathoides-medicinal plant extract for wound healing applications. Asian J Chem. 2013;25(Supplementary Issue):S311-4. [Link]
12. Choi YS, Hong SR, Lee YM, Song KW, Park MH, Nam YS. Study on gelatin-containing artificial skin: I. Preparation and characteristics of novel gelatin-alginate sponge. Biomaterials. 1999;20(5):409-17. [Link] [DOI:10.1016/S0142-9612(98)00180-X]
13. Ayoola GA, Coker HB, Adesegun SA, Adepoju-Bello A, Obaweya K, Ezennia EC, et al. Phytochemical screening and antioxidant activities of some selected medicinal plants used for malaria therapy in southwestern Nigeria. Trop J Pharm Res. 2008;7(3):1019-24. [Link] [DOI:10.4314/tjpr.v7i3.14686]
14. Kayani SA, Masood A, Achakzai A, Anbreen S. Distribution of secondary metabolites in plants of Quetta-Balochistan. Pak J Bot. 2007;39(4):1173-9. [Link]
15. Gao C, Liu M, Chen J, Zhang X. Preparation and controlled degradation of oxidized sodium alginate hydrogel. Polym Degrad Stab. 2009;94(9):1405-10. [Link] [DOI:10.1016/j.polymdegradstab.2009.05.011]
16. Ghashghaei F, Moazamian E, Jafari A, Askarian S, Derakhshandeh T. Effect of oak plum extract on burn infection caused by exotoxin A-producing Pseudomonas aeruginosa in mice. 2nd National Conference on Sustainable Medicinal Plants and Agriculture. Hamadan: Association of Environmental Assessors of Hegmataneh; 2014. [Persian] [Link]
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