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With the instrumentation of Mass Spectrometry (MS) and advances carried out in bioinformatic tools and databases, along with birth of nanotechnology in 1990s, biology experienced a dramatic revolution and new perspectives were found in molecular biology and medicine, agriculture, environmental sciences and pharmatiuticals. The most important one is systematic look at the entire organism and solving biological problems at the level of entire system viewed as an integrated and interacting network of genes, proteins and biochemical reactions (Systems Biology). In addition, :union: of biology and nanotechnology result in creation of nanobiotechnology. This paper provides an easy-to-read guide to the concepts of some of the major topics in today’s biology. Topics discussed here, include fundamentals of proteomics and systematic descriptions of the various types of studies in proteomics. After a brief review on the physical principles of nanotechnology, the application of one of its products, known as quantum dot in biology and particularly, proteomics studies, were discussed. This account covers the general principles and applications of new emerging fields in biology.

Keywords: Mass Spectrometry, Bioinformatics, nanotechnology, systems Biology, quantum dot

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