1- Malek Ashtar University of Technology
2- Malek Ashtar University of Technology , zeinoddini@modares.ac.ir
2- Malek Ashtar University of Technology , zeinoddini@modares.ac.ir
Abstract: (190 Views)
Gold nanoparticles (GNPs) with unique optical properties, such as easy operation and visualized assay, have a great ability to detect different types of analytes. Today, the use of gold nanoparticles has wide applications in the field of medicine and biotechnology, including the detection of microorganisms that cause contamination in water, air and food and it is considered a suitable alternative for chemical and physical methods. New technologies in the design of biosensors based on GNPs provide the ability to identify biological compounds accurately and quickly. One of these technologies is a detection sensor based on surface plasmon resonance (SPR), which based on its optical properties, is capable of very sensitive and specific measurement of biomolecule interactions without time delay. This technology can quantify in a short time the properties of biomolecular mediators (such as oligonucleotides, proteins and bacteria) on the surface, including reaction speed, tendency and concentration of surface mediators. In this review, while investigating the surface plasmon properties of gold nanoparticles, the simple diagnostic applications of gold nanoparticles based on the localized surface plasmon (LSPR) method and detection in biomedicine.
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