Volume 4, Issue 2 (2013)
JMBS 2013, 4(2): 65-73 |
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optimization of chitosan nanoparticles synthesis. JMBS 2013; 4 (2) :65-73
URL: http://biot.modares.ac.ir/article-22-7114-en.html
URL: http://biot.modares.ac.ir/article-22-7114-en.html
Abstract: (17391 Views)
Biodegradable polymeric nanoparticles are highly regarded in drug delivery due to bioavailability, better encapsulation, controlled release and low toxicity. Drug encapsulation in polymeric nanoparticles may improve the therapeutic effects of these compounds. Polymers are divided in two types: natural and synthetic. Chitosan, as a natural polymer, can have many applications in drug delivery due to good properies. The purpose of this study is to optimization of the production of chitosan nanoparticles for drug delivery. Chitosan nanoparticles were prepared according to ionic gelation method and characterized. Prepared nanoparticle morphology investigated using SEM and particle size distribution, and surface charge and polydispersity index (PDI) were determined by Nanozeta Sizer. FTIR spectra of the lyophilized samples were recorded and proved the formation of nanoparticles. This study has shown that the particle size and zeta potential can be controlled by a change in the ratio of the weight and volume of chitosan and pH adjustment.
Article Type: _ |
Subject:
biochemistry
Received: 2014/08/19 | Accepted: 2013/09/23 | Published: 2015/02/1
Received: 2014/08/19 | Accepted: 2013/09/23 | Published: 2015/02/1
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