Volume 11, Issue 4 (2020)                   JMBS 2020, 11(4): 1-15 | Back to browse issues page

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Abri A, Hasankhani S. Extraction and identification of Gallic acid and Protocatechuic acid from fruit juices of Rhus coriria and preparation silyl derivatives of these compounds to increase their lipophilic nature and drug's effectiveness. JMBS 2020; 11 (4) :1-15
URL: http://biot.modares.ac.ir/article-22-28778-en.html
1- Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz- IRAN, 35-Km Tabriz- Azarshahar road, Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz- IRAN,5375171379 , ar.abri@azaruniv.ac.ir
2- Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz- IRAN, 35-Km Tabriz- Azarshahar road, Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz- IRAN, Post Code: 5375171379
Abstract:   (1215 Views)
Aims: The aim of this study was to extract, isolate, purify, identify and determine the percentage of two natural combinations of protocatechoic acid and gallic acid from Sumac with high efficiency. These compounds exhibit good antimicrobial, antiviral, antifungal, anti-diabetic, anti-insect and parasitic and antioxidant properties. Subsequently, to enhance the drug efficacy of these compounds, their silyl derivatives were prepared.
Materials & Methods: The Rhus coriria plant from the trees of the Naghadeh, from the trees of the Aras Baran and from the trees of the Shitaneh village was collected. They were dried in the shadow and grinding. After extraction, to identify two important compounds and their silyl derivatives, we use FT-IR, 1H-NMR, 13C-NMR, GC-Mass, DSC, XRD and HPLC methods.
Findings: According to experiments, it can be concluded that the sample of Iranian Sumac fruits in Arasbaran region has the highest amounts of gallic acid (2.99%) and protocatechoic acid (2.902%). We also conclude that the type of soil and the location of growth of a genus are quite influential in its active ingredients, taste, and color. By silylation of these compounds, the lipophilic properties increase sharply, that is, they pass easily through the cell membrane and increase their judgment effect.
Conclusion: In this research work, two high-efficiency natural compounds were extracted from the samples of Sumac. Subsequently, due to their medicinal properties, silyl derivatives were prepared and their structure identified by spectroscopic methods. In this way, the permeability of the cell membrane easily done and the pharmacological effect of greatly increased.
 
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Article Type: Original Research | Subject: Pharmaceutical Biotechnology
Received: 2018/12/30 | Accepted: 2020/09/27 | Published: 2020/11/30

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