Volume 15, Issue 2 (2024)
JMBS 2024, 15(2): 0-0 |
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Bakhtiari N, Vaez M. Escherichia Coli: the most useful host for production of recombinant proteins. JMBS 2024; 15 (2)
URL: http://biot.modares.ac.ir/article-22-63755-en.html
URL: http://biot.modares.ac.ir/article-22-63755-en.html
1- Biotechnology department, Iranian research organization for science and technology, Iranian research organization for science and technology, Sh. Ehsani Rad St., Enqelab St., Ahmadabad Mostoufi Rd., Azadegan Highway , nbakhtiari@irost.org
2- biotechnology department, Iranian Research organization for science and technology
2- biotechnology department, Iranian Research organization for science and technology
Abstract: (503 Views)
One of the most important hosts used for production of recombinant proteins is Escherichia Coli. For example, the most therapeutic proteins approved by FDA are produced in Escherichia Coli. Comprehensive knowledge about biologic nature of Escherichia Coli had made this microorganism to a favorable factory for production of recombinant proteins. Accessibility of this information have led to rational manipulation for changing of this small factory to intelligent system can make different recombinant proteins easier. So that, many engineered and useful strains were obtained from wild type and parental strains can produce high amount of diverse and stable recombinant proteins in lab and industrial scale. In this review, we will present some of these strains that are more widely used.
Article Type: Analytic Review |
Subject:
Molecular biotechnology
Received: 2022/08/23 | Accepted: 2024/03/16 | Published: 2024/06/24
Received: 2022/08/23 | Accepted: 2024/03/16 | Published: 2024/06/24
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