A review of fibrin applications and itâs derivatives in wound healing and tissue engineering

Hasannia, Shahriar; Bahri, Mina; Gashtasbi, Fatemeh; Dabirmanesh, Bahareh

A review of fibrin applications and itâs derivatives in wound healing and tissue engineering

Document Type : Analytic Review

Authors

Shahriar Hasannia ¹

Mina Bahri ²

Fatemeh Gashtasbi ³

Bahareh Dabirmanesh ²

¹ Nova Teb Research Laboratory, Dental Equipment and Biomaterials Incubation Center, Tehran University of Medical Sciences, Tehran, Iran

² Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

³ Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Fibrinogen is a major component of the coagulation cascade following tissue damage and rapidly forms an insoluble fibrin scaffold. Fibrin is a filamentous biopolymer that naturally forms from fibrinogen polymerization during blood clotting. After tissue damage and coagulation cascade initiation, soluble fibrinogen polymerization by thrombin enzymebegins and forms an insoluble fibrin network and blood clots with platelets. This fibrin network is crucial for the development of homeostasis after tissue damage. This biopolymer also plays a key role in the wound healing as a temporary scaffoldand due to its unique structural properties and physiological function; it is used in reconstructive medicine. Fibrin is able to absorb extracellular matrix proteins (ECM) such as fibronectin and growth factors. The main types of fibrin scaffolds like platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) are being used as autologous biomaterials in reconstructive medicine, wound healing, orthopedics and skin reconstruction and cosmetic sciences. Fibrin derivatives and degradation products also play an important role in the process of wound healing by stimulating cell infiltration and tissue regeneration and they are being widely used in developing new products as a biological material for over a century.

Keywords

Fibrin

Homeostasis

Wound healing

Tissue engineering

20.1001.1.23222115.1399.11.3.9.2

Subjects

Industrial Biotechnology

1- Laurens N, Koolwijk P, de Maat MP. Fibrin structure and wound healing. J Thromb Haemost. 2006 May;4(5):932-9.
2- Standeven KF1, Ariëns RA, Grant PJ. The molecular physiology and pathology of fibrin structure/function. Blood Rev. 2005 Sep;19(5):275-88.
3- Mário A. Barbosa and M. Cristina L. Martins. Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair. Woodhead publishing. 2018, Pages 151-173
4- Ashley C. Brown and Thomas H. Barker. Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level. Acta Biomater. 2014 April; 10(4): 1502–1514.
5- Weisel JW, Litvinov RI. Mechanisms of fibrin polymerization and clinical implications.
Blood 2013;121: 17 12–9.
6- Weisel JW, Litvinov RI. Fibrin Formation, Structure and Properties. Subcell Biochem. 2017;82: 405-456.
7- Falvo MR, Gorkun OV, Lord ST. The molecular origins of the mechanical properties of fibrin. Biophys Chem. 2010 Nov;152(1-3):15-20.
8- Yeromonahos C, Polack B, Caton F. Nanostructure of the fibrin clot. Biophys J. 2010 Oct 6;99(7):2018-27.
9- Laurens N, Koolwijk P, de Maat MP. Fibrin structure and wound healing. J Thromb Haemost. 2006 May;4(5):932-9.
10- Alexandru Florian Grecu, Lucien Reclaru, Lavinia Cosmina Ardelean, Oliviu Nica, Eduard Mihai Ciucă and Marius Eugen Ciurea. Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment. Medicina 2019, 55, 141
11- Oncul O, et al. Effect of the function of polymorphonuclear leukocytes and interleukin-1 beta on wound healing in patients with diabetic foot infections. J Infect, 2007 ;54:250–6.
12- Neil Lagali, ConfocalL Laser Microscopy – Principles and Applications in Medicine, Biology, and THE Food Sciences. 2013, ISBN-10 953-51-1056-X, chapter 10; 189-199
13- A. Gonzalez, T. Fortuna Costa, Z. Andrade, and A. Medrado. Wound healing - A literature review. An Bras Dermatol. 2016; 91(5):614-20.
14- N. Ganapathy, S. S. Venkataraman, R. Daniel, R. J. Aravind, and V. B. Kumarakrishnan. Molecular biology of wound healing. J Pharm Bioallied Sci. 2012 Aug; 4(Suppl 2): S334–S337.
15- Bahri M, Hasannia S, Dabirmanesh B, Moshaverinia M, and Zadeh HH. A Multifunctional Fusion Peptide for Tethering to Hydroxyapatite (HA) and Selective Capture of Bone Morphogenetic Protein from Extracellular Milieu., Journal of Biomedical Materials Research: Part A, 2019, (Accepted)
16- Martino MM., Briquez PS, Ranga A, Lutolf MP, Hubbell JA. Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4563-8.
17- Park CH. and Woo KM. Fibrin-Based Biomaterial Applications in Tissue Engineering and Regenerative Medicine. Adv Exp Med Biol. 2018; 1064:253-261.
18- Barsotti MC, Felice F, Balbarini A, Di Stefano R. Fibrin as a scaffold for cardiac tissue engineering. Biotechnol Appl Biochem. 2011 Sep-Oct;58(5):301-10.
19- T. Rajangam and S. S. A An. Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications. Int J Nanomedicine. 2013; 8: 3641–3662.
20- Xu Y, Chen C, Hellwarth PB, Bao X. Biomaterials for stem cell engineering and biomanufacturing. Bioact Mater. 2019 Dec 2;4: 366-379.
21- Gersh KC, Nagaswami C, Weisel JW. Fibrin network structure and clot mechanical properties are altered by incorporation of erythrocytes. Thromb Haemost;102: 1169–7 5.
22- Jennewein C, Tran N, Paulus P, Ellinghaus P, Eble JA, Zacharowski K. Novel aspects of fibrin(ogen) fragments during inflammation. Mol Med. 2011 May-Jun;17(5-6):568-73. Epub 2011 Jan 4.
23- Qi J, Goralnick S, Kreutzer DL. Fibrin regulation of interleukin-8 gene expression in human vascular endothelial cells. Blood. 1997 Nov 1;90(9):3595-602.
24- Shiose S, Hata Y, Noda Y, Sassa Y, Takeda A, Yoshikawa H, Fujisawa K, Kubota T, Ishibashi T. Fibrinogen stimulates in vitro angiogenesis by choroidal endothelial cells via autocrine VEGF. Graefes Arch Clin Exp Ophthalmol. 2004 Sep;242(9):777-83.
25- Janmey PA, Winer JP, and Weisel JW. Fibrin gels and their clinical and bioengineering applications. J R Soc Interface. 2009 Jan 6; 6(30): 1–10.