Dengue fever disease: diagnosis, treatment and control strategies

Mardashti, Zahra; Zeinoddini, Mehdi; Fatollahi Arani, Samaneh; Shoushtari, Mohammad

Dengue fever disease: diagnosis, treatment and control strategies

Document Type : Analytic Review

Authors

Zahra Mardashti ¹

Mehdi zeinoddini ²

Samaneh Fatollahi Arani ¹

Mohammad Shoushtari ³

¹ Master's student in Molecular Biotechnology, Department of Biological Sciences, University Complex of Chemistry and Chemical Engineering, Malek Ashtar University of Technology, Tehran, Iran.

² PhD in Biochemistry, Associate Professor, Department of Biological Sciences, University Complex of Chemistry and Chemical Engineering, Malek Ashtar University of Technology, Tehran, Iran.

³ PhD in Virology, Department of Medical Virology, Institut Pasteur, Tehran, Iran

Abstract

Since 2012, dengue disease has been considered as one of the most important viral diseases transmitted through arthropods and has become one of the major health problems in tropical and subtropical regions of the world In recent years. This virus has four serotypes and is transmitted through the Aedes mosquito. The aim of this Work is to investigate methods for diagnosing, treating, and controlling dengue disease. The method of conducting the study was based on observation and interpretation of information obtained from relevant scientific articles and books. This study was conducted in the spring and summer of 1403 by checking keywords such as Dengue virus, Aedes aegypti, dengue vaccine, detection, protection, chemical control on NCBI, Google, PubMed, WHO search engines. The molecular methods (real-time PCR) and immunoassay are often used to detect dengue virus. In order to prevent the disease, it is also recommended to control the life cycle of Aedes mosquito and use of quadrivalent live and attenuated Dengvxia and TAK-003 vaccines. The clinical treatment of this disease is done using serum therapy and the use of liquids. Finally, chemical and biological control methods of Aedes mosquito are also recommended as strategies to deal with this disease. In this review article, while describing the specific characteristics of dengue virus, the diagnostic and treatment methods of this disease have been scientifically investigated. It is also presented how to prevent control of this disease.

Keywords

Dengue virus

Aedes mosquito

vaccine

Identification

Treatment

Control

Subjects

Molecular biotechnology

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