Volume 9, Issue 2 (2018)                   JMBS 2018, 9(2): 187-192 | Back to browse issues page

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1- Bioelectric Department, Biomedical Engineering Faculty, Amirkabir University of Technology‎, Tehran, Iran
2- Bioelectric Department, Biomedical Engineering Faculty, Amirkabir University of Technology‎, Tehran, Iran, Bioelectric Department, Biomedical Engineering Faculty, Amirkabir University of Technology, Hafez Street, Tehran, Iran. Postal Code: 1591634311 , msaviz@aut.ac.ir
Abstract:   (9246 Views)
Aims: Computation of the field distribution and the penetration of electromagnetic fields induced in the body and biological tissues are one of the major issues discussed in the bioelectromagnetic field; with access to the geometry of the cell and its organelles, the contribution of each component to the field's reception and the field distribution as well as the computation of impedance can accurately be estimated. The aim of this study was to create 3D geometric models of cells and organelles for bioelectromagnetic simulations.
Materials and Methods:  The present study is a computational research study. In this study a complete electrical model for several cell types of the epidermis layer of human skin with its organelles was created by SAVI 1 software and innovative new algorithms. In this geometric model, organelles such as mitochondria, Golgi body, melanin pigments, ribosome, lysosome, and intracellular nucleus were considered. The microscopic 2D image was used to create organelles.
Findings: The geometric model was created for the organelles and the cellular sample was created for all layers of the epidermis in accordance with reality. The cells of basal cortex were nucleated in cubic form, the cells of spinosum cortex were polygonal and nucleated, the cells of granular cortex were flat and nucleated, and the stratum corneum had complete flat cells without nucleus.
Conclusion: Creating 3D geometric model of cells and organelles within it is possible for bioelectromagnetic simulations. This 3D model can be saved in mat, stl, and vox formats and retrieved in SAVI, CST studio, and MATLAB software.
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Subject: Agricultural Biotechnology
Received: 2016/10/5 | Accepted: 2017/05/26 | Published: 2018/06/21

1. Aberg P, Nicander I, Hansson J, Geladi P, Holmgren U, Ollmar S. Skin cancer identification using multifrequency electrical impedance-a potential screening tool. IEEE Trans Biomed Eng. 2004;51(12):2097-102. [Link] [DOI:10.1109/TBME.2004.836523]
2. Huclova S, Erni D, Fröhlich J. Modelling effective dielectric properties of materials containing diverse types of biological cells. . J Phys D, Appl Phys. 2010;43(36):365405. [Link] [DOI:10.1088/0022-3727/43/36/365405]
3. Urken ML, Mehra S. About the head & neck cancer guide [Internet]. New York: THANC Foundation; 2016 [cited 2016 May 22]. Available from: https://headandneckcancerguide.org/about/ [Link]
4. Saviz M, Faraji Dana R. Realistic cell and organelle shape modeling for computational bioengineering: A new open-source toolbox. 2014 22nd Iranian Conference on Electrical Engineering (ICEE). New Jersey: IEEE; 2014. [Link]
5. Huclova S, Erni D, Fröhlich J. Modelling and validation of dielectric properties of human skin in the MHz region focusing on skin layer morphology and material composition. J Phys D, Appl Phys. 2012;45(2):025301. [Link] [DOI:10.1088/0022-3727/45/2/025301]
6. Zelickson AS, Hartmann JF. An electron microscopic study of human epidermis. J Investig Dermatol. 1961;36(2):65-72. [Link] [DOI:10.1038/jid.1961.14]
7. Schmitz G, Müller G. Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids. J Lipid Res. 1991;32(10):1539-70. [Link]
8. Klein‐Szanto AJ. Clear and dark basal keratinocytes in human epidermis, a stereologic study. J Cutan Pathol. 1977;4(5):275-80. [Link] [DOI:10.1111/j.1600-0560.1977.tb00916.x]
9. Sathananthan AH. Human cell and tissue fine structure for teaching and research in stem cells. 1st Volume. Sri Lanka: Professor Arunachalam Henry Sathananthan; 2015. [Link]
10. Hartinger AE, Guardo R, Kokta V, Gagnon H. A 3-D hybrid finite element model to characterize the electrical behavior of cutaneous tissues. IEEE Trans Biomed Eng. 2010;57(4):780-9. [Link] [DOI:10.1109/TBME.2009.2036371]
11. Walker DC, Brown BH, Smallwood RH, Hose DR, Jones DM. Modelled current distribution in cervical squamous tissue. Physiol Meas. 2002;23(1):159. [Link] [DOI:10.1088/0967-3334/23/1/315]
12. Gabriel S, Lau RW, Gabriel C. The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues. Phys Med Biol. 1996;41(11):2271. [Link] [DOI:10.1088/0031-9155/41/11/003]

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