Volume 11, Issue 3 (2020)                   JMBS 2020, 11(3): 15-22 | Back to browse issues page

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1- Nova Teb Research Laboratory, Dental Equipment and Biomaterials Incubation Center, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3- Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran , Dabirmanesh@modares.ac.ir
Abstract:   (9122 Views)
Fibrinogen is a major component of the coagulation cascade following tissue damage and rapidly forms an insoluble fibrin scaffold. Fibrin is a filamentous biopolymer that naturally forms from fibrinogen polymerization during blood clotting. After tissue damage and coagulation cascade initiation, soluble fibrinogen polymerization by thrombin enzymebegins and forms an insoluble fibrin network and blood clots with platelets. This fibrin network is crucial for the development of homeostasis after tissue damage. This biopolymer also plays a key role in the wound healing as a temporary scaffoldand due to its unique structural properties and physiological function; it is used in reconstructive medicine. Fibrin is able to absorb extracellular matrix proteins (ECM) such as fibronectin and growth factors. The main types of fibrin scaffolds like platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) are being used as autologous biomaterials in reconstructive medicine, wound healing, orthopedics and skin reconstruction and cosmetic sciences. Fibrin derivatives and degradation products also play an important role in the process of wound healing by stimulating cell infiltration and tissue regeneration and they are being widely used in developing new products as a biological material for over a century.


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Article Type: Analytic Review | Subject: Industrial Biotechnology
Received: 2020/03/29 | Accepted: 2020/06/29 | Published: 2020/10/2

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