1- 1. Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2- Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran ,parviz@modares.ac.ir
3- Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
2- Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran ,
3- Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
Abstract: (26 Views)
The recent developments in scientific advancements notably enhanced the understanding of the complex relationship between cancer and the microbiome.Various experimental studies demonstrated that the interaction between the host and microbiota plays a crucial role in the health or disease of the human body. The human microbiome has various benefits, including regulating fundamental processes such as signal transmission, immunity, and metabolism, which contribute to the proper functioning of the host. The imbalance of intestinal microbiota or dysbiosis is associated with the onset and progression of complex diseases such as colorectal cancer(CRC). Motivated by these, in this research, by utilizing metagenomic and metabolomic data and functional analyses of the colon microbiome, we have identified bacteria, metabolites, and important bacterial pathways in colorectal cancer compared to the healthy control group. Also, we investigated the role of different bacteria in pathways with significant abundance. Ultimately, by analyzing the network of bacteria-metabolite interaction in both healthy and cancer groups, we identified the differences between these two networks in terms of topological parameters. Our findings introduced potential biomarkers for CRC that could be used in future research orientation. Furthermore, it highlighted that some bacteria, such as Bacteroides fragilis and Bifidobacterium longum, which had increases and decreases in abundance in the cancer group, respectively, also contribute to key bacterial biological pathways in CRC. These findings underscore the potential of the gut microbiome as a promising non-invasive approach for early CRC screening, emphasizing the significance of gut microbiota composition and their metabolites in providing valuable insights into CRC.
Article Type: Original Research |
Subject:
Molecular biotechnology
Received: 2024/07/31 | Accepted: 2024/11/9
Received: 2024/07/31 | Accepted: 2024/11/9
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