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Showing 3 results for Ali Akbari
Volume 7, Issue 1 (Winter 2022)
Abstract
Aim: Patient safety is one of the most important parameters of quality health care. The role of health care workers in providing safe care is essential, and their positive attitudes towards this issue will positively affect patient safety. This review aimed to investigate the attitudes of health care workers towards patient safety in Iran.
Method and Materials: The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guideline was used to conduct the present review. Data resources including SID, Magiran, Scopus, PubMed, ISC, Web of science, and Google Scholar were chosen to conduct the literature search both in Persian and English without any time limit until the end of January 2021. Inclusion criteria included all English or Persian language studies in which the Safety Attitude Questionnaire (SAQ) was used to assess the attitude of Iranian health care workers towards patient safety.
Findings: In the primary search, 342 studies were obtained, finally 11 of which were reviewed. Among these, 10 studies had cross-sectional designs, and one study was a quasi-experimental research. Overall, 2162 health care workers were analyzed. The results of the present study showed that most health care workers in Iran had unfavorable attitudes towards patient safety.
Conclusion: As upgrading health care workers’ attitudes seems necessary to improve patients’ safety, it is recommended that health organizations provide regular patients’ safety training, both at employment time and during service to the health care workers who are in direct and indirect contact with patients.
Narges Nasrollahi Boroujeni, Farhang Ali Akbari, Dina Morshedi,
Volume 14, Issue 2 (5-2023)
Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and the prevalence of it has increased worldwide. PD causes severe damage to loss of midbrain dopaminergic neurons (DN) at substantia nigra which involves in the movement control. The synaptic terminals of DNs are destroyed in the posterior putamen. PD is also characterized by accumulation of misfolded and amyloid α-synuclein into proteinous inclusions named Lewy bodies. So far there is no effective treatment for PD and approved medications for PD can only slow down clinical progression, control motor and non-motor symptoms. Currently, the approved medications just induce the release of dopamine and prevent the release of acetylcholine from nerve terminals of caudate cholinergic interneurons and it is necessary to provide more effective treatment methods in the early stages of the disease. Significant progress has been achieved in development of drugs that can reduce neuronal cell death and lead up to neuroprotection, however targeting delivery of drugs to improve the pharmaceutical effects of drugs is remained as a challenge. Therefore, there is a pressing demand to find practical strategies for delivering these pharmaceuticals in vivo through the BBB without disrupting the brain's functions. In this regard, Focused ultrasound (FUS) technology eliminates the need for brain surgery and temporarily opens the blood-brain barrier to allow drugs to pass through. In this review, the application of FUS as a new drug delivery application in the PD models and the potential clinical application of neuroprotective agents are provided briefly.
Volume 15, Issue 3 (10-2012)
Abstract
Objective: Biodegradable polycaprolactone/starch composites can be used for bone tissue engineering applications. The effect of the ratio of components on composite properties is of tremendous importance. Methods: Polycaprolactone/starch composite of 80/20 and 70/30 ratios were fabricated by dissolving them in chloroform followed by evaporation of the solvent. Results: The composites were characterized by fourier transform infrared spectroscopy. Their bioactivity was evaluated by studying the apatite formation ability after immersing the specimens in simulated body fluid. The results of compressive test on samples showed that the composite’s modulus and strength approximated that of human trabecular bone. Mass loss in distilled water and starch degradation rate in PBS was evaluated, which showed that the starch ratio was effective in composite degradation. MTT analysis and alkaline phosphatase levels showed that this composite had no toxicity and could increase G-299 cell line osteoblastic activities. Conclusion: The increase in cellular osteoblastic activities and the ability for apatite formation on the composite surface, in addition to the polycaprolactone/starch samples' mechanical properties shows their capability to be used as substitutes for bone. Because this composite degradation rate is controlled by changing the starch ratio, it has the potential for use in bone tissue engineering applications. Samples that have a 70/30 ratio are considered optimal due to their enhanced cellular response and better mechanical properties.
