Showing 6 results for Bozorgmehr
Fatemeh Bozorgmehr, Mehdi Zeinoddini, Abbas Azimifard, Noor Mohmmad Danesh,
Volume 14, Issue 1 (FALL 2023)
Abstract
Aptamers or chemical antibodies are mostly nucleic acid sequences that can bind to various diverse targets including small molecules, large molecules, and cells. Among the advantages of aptamers compared to antibodies, we can mention the in vitro production process, the possibility of choosing aptamers against toxic and non-immunogenic molecules, long-term storage, and much lower production costs. Aptamers can also be easily modified or stabilized, and their synthesis is associated with high purity and reproducibility, they are chemically stable, and due to their nucleic acid structure, they are much more flexible than antibodies, and they can be used in the form of molecular beacons probes, a combination of use aptamer-target interaction and nucleic acid amplification to achieve highly sensitive detection ranges. These interesting features have made aptamers ideal diagnostic elements for analytical tools such as biosensors, colorimetric methods, surface plasmon resonance, and lab-on-a-chip. However, all these methods require skilled workers and laboratory-based instruments, thus limiting their application. In this regard, lateral flow assay or paper strip kits provide fast and reliable results and only require user intervention in the sample addition phase. Due to their simplicity is widely used in various fields including medicine, food product quality inspection, and environmental safety. In this work, while introducing aptamers, , an overview of its unique application in lateral flow assay and the future of this technology should be studies.
Volume 14, Issue 4 (3-2012)
Abstract
Objective: Menstrual blood stromal stem cells (MBSCs) share some phenotypic and functional similarities with mesenchymal stem cells (MSCs). MSCs are shown to inhibit either the function or generation of different immune cells, including dendritic cells (DCs). However, data regarding MBSCs’ potential effects on immune system cells are elusive. Here, we examine whether MBSCs affect the generation of human monocyte-derived DCs.
Methods: Menstrual blood samples were collected from apparently healthy women on the second day of their menstrual cycles. The adherent portions were subcultured to omit unwanted cells and obtain MBSCs. Magnetically-isolated peripheral blood monocytes were differentiated towards DCs through treatment with recombinant granulocyte monocyte colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) in the presence or absence of MBSCs. After five days, monocyte-derived DCs were analyzed for the expression of surface markers by flow cytometry. IL-6 level was determined in the co-culture supernatants.
Results: Co-culture with MBSCs significantly down regulated the expression of DC marker (CD1a) and up regulated the expression of monocyte marker (CD14) on monocyte-derived DCs compared with the control group. IL-6 level was shown to be significantly higher in the supernatant of the monocyte-MBSC co-culture.
Conclusion: Collectively, this is the first study to show the inhibitory impacts of MBSCs on the generation of DCs. IL-6 could be viewd as a potential factor mediating this effect. Regarding the known advantages over MSCs, MBSCs could be considered as a promising future candidate for immunomodulatory purposes in the clinical setting.
Volume 18, Issue 6 (12-2018)
Abstract
Several studies have been done on the rheological properties and setting time of cementitious mixes, but the relationship between these two important features has not been studied so far. Therefore, the aim of this study is to investigate the relationship between rheological properties and setting time in self-consolidating concrete mixtures. In this study, six self- consolidating concrete mixture proportions were considered, in which the effect of water-cement ratio changes, silica fume and slag was used. The electrical resistivity method has been used in determining its setting time, and the performance of this method has been evaluated in determining the rheological properties. Since the electrical resistivity method is not standardized in determining the setting time, therefore, to verify the results, the standard penetration resistance method is also used according to the ASTM-C403. In the study of rheological properties, the studies have been done in two sections of efficiency and rheometer analysis. From the results, it was found that mixtures that have higher slump flow have recorded less time to take. It was also found that concrete mixtures that have higher yield stress (static and dynamic) have shorter setting time. In this way, the relationships between these two important variables (rheological properties and setting time) were evaluated by the relationships.
Volume 24, Issue 2 (Summer 2020)
Abstract
Introduction: The development of the tourism industry and its positive effects on human societies have been emphasized in most parts of the world, while the uneven development of tourism has led to negative effects and consequences in society and has received less attention.
2- Methodology: In this study, analysis of the damages and negative consequences of uneven urban tourism development in district 22 of Tehran have been studied from the viewpoints of citizens and experts. The statistical population of the study consisted of include the citizens of district 22 of Tehran and experts of the municipality. According to Cochran's formula, 385 citizens participated in the study by random sampling. 45 Experts also participated in the study with 45 people by non-random and accessible participants sampling. In order to prioritize damage indices and items, the mean Likert type scale was used. For analytical purposes of this study and to compare means of tourism damages between citizens and experts, independent t-test was used. Data were analyzed using SPSS software.
3- Results and Discussion: The results showed that there was a statistically significant difference between citizens and experts in spatial-physical, economic, and socio-cultural indices. The environmental impacts of uneven tourism uneven development in district 22 of Tehran has been more important for experts, but spatial-physical damage has become more important and the first priority from the viewpoints of the citizens.
4- Conclusion: The result of this study highlights the importance of environmental index and its ensuing consequences from the viewpoints of experts. But according to citizen’s citizens’ opinions, issues such as urban traffic, access to services and markets and uneven construction are more important.
Volume 27, Issue 2 (Summer 2023)
Abstract
In Iranian law there are two theories in interpretation of the contract: the theory of "Interpretation Based on the Common Intention of the Parties" vs. the theory of "Sociological and Free Interpretation". In American law,"Textualism" and "Contextualism" are the most important theories of contract interpretation. Other theories have been proposed in American law, which include: "Literalism","Subjectivism","Objectivism" and "Objective - Contextual Interpretation" which is a combination of subjectivist and objectivist approaches. The main question is what are the strengths and weaknesses of the interpretation theories, and what relationship can be established among the theories of contract interpretation in Iranian and American law. In the present study, it has been determined by the descriptive-analytical method that in American law, although contextualist and subjectivist theories claim to best discover the real intention of individuals as the main goal of interpretation and fully guarantee the "Principle of Free Will", It seems that although Textualism and Objectivism maintain legal values such as the stability of transactions and trust in the legitimate intentions of individuals, at the same time they also provide economic values such as efficiency and maximum profit in transactions. Therefore, in interpretation of the contract, Textualism with an objective approach is superior to Contextualism and Subjectivism. Lack of reliance on textual interpretation theories and inattention to economic criteria such as efficiency and maximum profit are the major weaknesses of contract interpretation theories in Iranian law.The interpretation of the contract with the inner intention approach in Iran is related to subjectivist and contextualist theories, and the interpretation based on apparent intention can be considered close to objectives and textual theories.
Volume 27, Issue 4 (12-2023)
Abstract
The independence of directors means the ability to think and make decisions freely, taking into account the interests of the company and shareholders and without being influenced by factors that cause conflicts of interest with corporate rights. Undoubtedly, the independence of directors has been able to significantly increase the efficiency of the companies' board of directors, and in the meantime, the basic assumption has been that the directors of companies make independent decisions based on their own merits and regardless of personal interests or emotional affiliations. This article, with descriptive-analytical method seeks to prove that today, it is not correct to talk about the assumption of independence which is assumed for them in the decision-making position due to the norms, changes and structural bias, psychological realities such as group thinking prevailing in the board of directors and maybe directors do not want to invoke this right in practice because of maintain their position, common interests and their relationships with others directors.
