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Showing 2 results for Farasat
Volume 12, Issue 3 (12-2022)
Abstract
Culture has a direct impact on project processes, especially the initial process of the project, this issue is more pronounced in multinational projects or environments with high cultural complexity. According to the literature review, it seems that the existing theories and models have neglected the influence of cultural factors on the performance of initial project management processes and the lack of a clear theoretical framework to explain the performance of initial project management processes that requires attention to cultural factors in the literature. it is obvious. In this study, considering the gap in the literature in the field of studying the role of culture in the initial processes and early actions of projects, the study of cultural components affecting the performance of the initial processes of project management has been considered. Due to the fact that there is no clear theoretical framework in the literature to analyze the above problem, in this study, qualitative research method and GT-based methodology with Strauss and Carbin approach have been used. Based on the analysis of the findings, it seems that national cultural factors such as "short-sightedness", "partiality", "unplannedness", "haste", and "convenience-seeking", as well as professional cultural factors such as: "lack of language" Common between project pillars "," project pillars mismatch "," client's pleasant preference for reality "," disbelief in project management standards "," disbelief in documentation "and" technical overcoming of project management ", paving the way for" hasty start " Projects "is in the country.
Mohammad Tohidlou, Sanam Sadeghi-Mohammadi, Mohammad Ghorbani, Zahra Vaezi, Alireza Farasat, Majid Taghdir, Hossein Naderi-Manesh,
Volume 15, Issue 1 (3-2023)
Abstract
Matrix metalloproteinases (MMPs) are a zinc endopeptidase family that increases the metastatic behavior of human malignant tumors. Epigallocatechin gallate (EGCG) is a major component of green tea polyphenols and is used as an MMP inhibitor in cancer treatment. This study aims to develop and optimize the loading of EGCG in the liposomal delivery system in an experimental/ computational way. In this study, nanoliposomes were prepared by passive loading and thin-film hydration method. Size, zeta potential, stability, encapsulation efficiency, and nanoliposome drug release profile were investigated. Cytotoxicity of nanoliposomes was evaluated on three breast cancer cell lines using an MTT viability assay. To investigate the EGCG-Liposome interaction, coarse-grained Molecular Dynamic simulations were carried out. The mean diameter of liposome was 73.6±6.9 nm, the surface charge was -14.6 mV and the encapsulation efficiency was 78.5±7.3%. The encapsulation of EGCG into the liposome caused a continuous release of the drug after 72 h, which also increased the potency of the drug. Due to the EGCG hydrophobic properties, the major distribution is located at the hydrophobic part of the membrane. The energy and radial distribution function results indicate the stability of liposomes. Simulation results demonstrate that the majority of the drug is surrounded by liposomes, which indicates high encapsulation efficiency and confirms the developed synthesis method. Due to the low solubility of the drug, it seems that the use of liposomal carriers to deliver and release EGCG is a suitable solution to increase the efficiency of the drug.
