Showing 3 results for Ghezelbash
Volume 7, Issue 2 (Spring 2021)
Abstract
Backgrounds: Nowadays, the need for replacement of new drug structures is felt more than ever due to the spread of microbial resistance. S-triazoles are significant five-membered heterocyclic scaffolds due to their wide range of biological activities.
Materials & Methods: A new series of Schiff bases (5a-f) were synthesized by the reaction of 4-amino-S-triazoles (3a-c) with furan and benzaldehyde 4(d-e). Then a novel series of triazole thioglycosides (7a-f) were synthesized by the reaction of Schiff bases (5a-f) and T-O-acetyle-α-D-glucopyranosyle-Br in the presence of potassium carbonate as a weak base in acetone. The structure of the products was confirmed by FT-IR, H-NMR, and C-NMR assays. The antimicrobial properties of the newly synthesized compounds were studied against four bacterial strains, including Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, and two fungal strains, including Aspergillus niger and Candida albicans.
Findings: The synthesized compounds exhibited better antifungal activity than antibacterial activity, espetially 7d. Among all the compounds, the compound 7d was found to have the highest activity against C. albicans with IZ=18±0.7 mm, MIC=250 mg/mL, and MFC= 250 mg/mL.
Conclusion: The present study results indicated that compounds containing S-triazole had the potential to be used in a wide variety of new antifungal formulations.
Volume 12, Issue 47 (7-2015)
Abstract
Xylitol is a naturally five – carbon polyol with a high sweetening power. Owing to its physicochemical and technological properties, make it of high value to pharmaceutical, food and chemical industries. The biotechnological method of producing xylitol by microorganisms has been studied as an alternative to the chemical method. This method is of interest because it requires little energy and is very specific. Among the microorganisms, yeasts are considered as the best xylitol producer. In this study xylitol was produced by Rhodotorola mucilaginosa that isolated from leaf of Benjamina. The produced xylitol by R. mucilaginosa was determined and measured by thin layer chromatography, kit and colorimetric methods. This strain produced 6.42 g l-1 xylitol after 48 hours in medium congaing of 40 g l-1 xylose. Consequences of increasing the initial xylose concentration from 60 to 140 g l-1, the final xylitol concentration and yield were also increased. Maximum concentration of produced xylitol by R. mucilaginosa was 49.28 g l-1 (yield of 0.59 g g-1) at 140 g l-1 initial xylose concentration. However further increasing of xylose concentration to 160 g l-1, led to a drastic decrease in xylitol production and yield.
Gholam Reza Ghezelbash, Arezoo Karami,
Volume 16, Issue 1 (12-2024)
Abstract
The process of soil and concrete cementation through microbial induction depends on the efficiency of the enzymes in producing bacteria. The isolation of microorganisms with high urease activity may lead to the isolation of strains that are better at cementing in compression to the current strains. This research deals with the isolation of isolates with high urease ability. Isolate 233 out of 283 isolates was associated with the best urease activity, and its urease activity was the release of 5.04 micromoles of ammonium per millilitre per minute. This isolate using sequencing of a fragment of 16SrRNA and characterization of biochemical properties was identified as Lysinibacillus sp. strain 233 was deposited in NCBI under accession number OQ379213. The semi-quantitative XRD analysis of the bacterium's calcite crystals in the precipitation medium revealed that 87.1% were calcite while only 12.9% were vaterite. FESEM electron microscope images revealed cubic calcite crystals and EDX analysis confirmed the presence of its constituent elements, i.e., carbon, oxygen, and calcium.