Based on the mental health comprehensive plan of development expression in 2015, mental disorders owned the second place of illnesses in Iran and residents of urban areas are the majority of the groups that most had been suffering from mental disorders. Therefore, urban living is a risk factor for residents’ mental health. While the issue of mental health and health is finding an acceptable place in urban design knowledge in global research, only in the last few years this study field has been considered in Iran with respect to the physical aspect of health and the psychological dimension of health remains neglected. Therefore, the purpose of the present study is to examine the relationship between mental health and urban environment and to propose a conceptual framework aimed at promoting mental health through urban design. In the present qualitative study, the data collection is done through desk study of related valuable scientific papers, and qualitative content analysis is used to extract the urban design qualities related to mental health. The validity of conceptual framework is done through interviews with experts in the fields of urban design and psychology, and completing the questionnaire and data analysis has been done using descriptive statistics. The results show that qualities such as "safety and security", "access to green-blue space", "permeability and walkability", "public realm quality", "place attachment", and "environmental cleanliness" in the substantive dimension and "social interaction and engagement" in the procedural dimension are related to residents’ mental health.

Aims: The G-quadruplex structural motifs of DNA are considered a novel target for drug discovery. As potential compounds, small molecules that selectively target the G-quadruplex structures may be used for therapeutic purposes. The aim of this study was the thermodynamic investigation of copper porphyrazines and phthalocyanine interaction with human telomeric G-quadruplex DNA.
Materials and Methods: In the present experimental study, interaction of an anionic water-soluble phthalocyanine Cu(PcTs) and two cationic water-soluble tetrapyridinoporphyrazines, including [Cu(2,3-tmtppa)] ⁴⁺ and [Cu(3,4-tmtppa)]⁴⁺ complexes with human telomeric G-quadruplex DNA was thermodynamically investigated in different concentrations of Na⁺ and K⁺ cations, using fluorescence spectroscopy. The data were analyzed via the Stern-Volmer plot and the van't Hoff plot.
Findings: Fluorescent intercalator displacement indicated the displacement ability of the complexes with thiazole orange. Stern-Volmer plots of the porphyrazines exhibited a slight positive deviation from a straight line, suggesting both static and dynamic quenching. In addition, the quenching effect of the two porphyrazines was noticeably higher than the phthalocyanine, implying binding of Cu(PcTs) to both forms of the quadruplex was weaker compared to Cu(2,3-tmtppa) and Cu(3,4-tmtppa). Gibbs free energy (∆G) for binding was negative, implying that the interaction between the complexes and the G-quadruplex DNA was favorable thermodynamically.
Conclusion: The binding of copper porphyrazines to G-quadruplex DNA is stronger than copper phthalocyanine, and their binding is favorable thermodynamically. Porphyrazines have potential to be used as anti-cancer compounds and are suitable complexes for pharmaceutical studies.