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Showing 2 results for Hasheminasab
Volume 8, Issue 2 (Summer 2018)
Abstract
Introduction The thoughts of Sheikh Ishraq (Shahāb ad-Dīn” Yahya ibn Habash Suhrawardī) have a high status in the Islamic world. These thoughts spread in the Safavid era, so that, more than ever, they became an important and influential category in the Islamic world. Since the art of architecture is the manifestation of the thoughts and mentalities of the architects and thinkers of each historical period, it can be expected that Suhrawardi’s thoughts are also manifested in the field of architecture. The main question of the research is whether the philosophy of Ishraq has influenced the Esfahani architectural style? And if so, how was this impact on the structure of the buildings of that era? In the following, using the interpretive-historical research method, the analysis of the views of Sheikh Ishraq and its comparative comparison with the architectural works of Esfahan doctrine were discussed. Then, using analytical-descriptive techniques, the correspondences between Suhrawardi’s thoughts and the architectural field of Esfahani style were explained. The data collection method is done by library research and referring to architectural documents.
Conclusion Studies conducted indicate that Esfahani style is significantly in line with the thoughts of Sheikh Ishraq. The various manifestations of light in the architecture of hierarchy, colors and decorations, empty space, the principle of plurality in unity, altar, golden dome, and so on can be considered as the effects of light in the architecture of this era.
Ali Fasihi, Hossein Nemati, Farnoush Kabiri, Hoda Hasheminasab, Bahram Mohamad Soltani,
Volume 14, Issue 3 (2-2024)
Abstract
The activity of Wnt signaling pathway is increased in colorectal cancer. For this reason, finding new positive and negative regulators for this pathway is a treatment and diagnostic strategy of colorectal cancer. Our bioinformatics analysis indicated that hsa-miR-424 (miR-424) could be a possible regulator of the Wnt signaling pathway. Accordingly, the expression level of miR-424 in colorectal cancer tissues was elevated compared with normal pairs and the results of RT-qPCR showed a significant increase in miR-424 expression (p < 0.01). Then, molecular analyzes using Top/Fop Flash and RT-qPCR techniques indicated that miR-424 overexpression leads to increased Wnt pathway activity in the SW480 cell line. In addition, the small molecules IWP-2 and PNU-74654 were used to inhibit the Wnt signaling pathway, and the miR-424 overexpression suggested that exert its effect on the level of β-catenin complex degradation. Then, dual-luciferase assay validated the interaction between miR-424 and APC. Overall, our results suggest miR-424 is a positive regulator of the Wnt signaling pathway, and it could be a possible prognosis for colorectal cancer.