Showing 11 results for Mirzapour
Volume 3, Issue 4 (12-2017)
Abstract
Background: Parasitic infections can cause different chemical changes in human body. This study was designed to determine the liver aminotransferase changes in Iranian people infected by parasite.
Materials and Methods: In this cross-sectional study, blood samples were collected from 183 parasite-infected patients. After serum isolation in laboratory, Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) rates of all samples were measured according to IFCC standard method, and after recording in the information form, the results were analyzed using descriptive statistics.
Results: The results of this study showed that patients were infected by 19 different types of parasites. Also, the results showed that the average value of ALT and AST in patients were equal to 32.30 ±23.40 and 38.60±34.80, respectively. The ANOVA test showed remarkable statistical differences between these values and various infections. There was positive and significant correlation between ALT and AST.
Conclusion: The abnormality in liver function in patients with eosinophilia can be caused by parasitic infections in endemic areas; therefore, it can be the cause of a differential diagnosis for physicians. Generally, non-significant changes in transaminase levels can also be attributed to the infection low intensity in patients tested.
Zeinab Bagheri, Aboulfazl Mirzapour,
Volume 13, Issue 1 (3-2022)
Abstract
Rapid test methods are laboratory instruments that can be used in the point of care and for suspicious cases. In an ideal rapid detection method, the steps for preparing a sample to obtain an analytical result should be as short as possible, and unskilled operators should be able to execute it and understand the result. To accomplish such a process, it is better to perform all the steps including sample preparation, detection procedure and acquisition of an intelligible signal in one device. These assay systems can include microfluidic chips, paper-based sensors, or even single-tube reactions. Corona Pandemic offers many products for the rapid detection of the Covid 19 virus, which diffrent products were commercially developed. Due to the sensitivity of the diagnosis at different stages of the disease, only a small number of technologies could be applied in practice. In this review article, these products are categorized and reviewed based on technological properties. Also, these technologies have been compared in terms of important components such as sensitivity, accuracy, cost and speed of the process in the diagnosis and management and control of COVID-19 pandemic. Also the application of each technology is explained. Finally, the best technology that can play a major role is introduced.
Volume 15, Issue 1 (Spring 2015 2015)
Abstract
In this article, we examine Samuelson's hypothesis on maturity effect in gold coin futures contracts traded in Iran Mercantile Exchange (IME). According to this hypothesis, the volatility of futures prices increases as future contracts approaches expiration date. The results show that the maturity effect is so weak in future contracts under investigation. This effect is acceptable in 5 out of 29 contracts. These contracts have been traded from 25 November 2008 to 21 September 2012. There are two different hypotheses on maturity effect in future contracts; the state variable hypothesis and negative covariance hypothesis. The state variable hypothesis states that the variability of futures prices is systematically higher in those periods when relatively large amounts of supply and demand uncertainty are resolved, i.e., during periods in which the resolution of uncertainty is high. According to negative covariance hypothesis, maturity effect is more likely to hold in markets that exhibit negative covariance between changes in spot prices and changes in net carry costs. Using panel data and Ordinary Least Square (OLS) techniques, we conclude that no hypothesis is held for IME gold coin futures contracts.
Shahab Sepanloo, Maisam Jalaly, Aboulfazl Mirzapour, Ali Parsay,
Volume 16, Issue 1 (12-2024)
Abstract
It is inevitable to replace the tissues and organs that were disrupted due to trauma or various diseases. One of the methods that can help to speed up the regeneration of wounds is to improve the technology of wound dressings. In the current research, by using the properties of polyurethane nanofibers and improving their properties with additives including graphene oxide, selenium nanoparticles, and henna plant extract, it was aimed to improve the performance of wound dressings. After finding the optimal concentration for the electrospinning machine, DMSO solution containing 12 wt.% polyurethane was used to produce wound dressing nanofibers. The images from scanning electron microscope (SEM) confirmed the production of uniform scaffolds composed of polyurethane nanofibers. Antibacterial properties and mechanical properties of the fabric were studied to check the performance of the manufactured fabric as a wound dressing. For the PU-GO-Se-Henna composite sample, the antibacterial activity against two bacteria, S.aureus and E.coli, was 3.26 and 2.85, respectively, which indicates the very attractive antibacterial properties. This sample reached a tensile strength of 92 MPa in the tensile test, which showed a 104% increase in strength compared to the pure polyurethane sample.
Volume 19, Issue 1 (5-2016)
Abstract
Objective: This study aims to investigate the testes cultures of patients with previous histories of maturation arrest in spermatogenesis and find the appropriate methods to overcome this problem.
Methods: We divided spermatogonial stem cells (SSCs) isolated from testes biopsies into 3 groups: 1) culture of SSCs without feeder layer; 2) co-culture of SSCs with patient-derived Sertoli cells; and 3) co-culture of SSCs on Sertoli cell feeder layer derived from healthy donors. We calculated the numbers and diameters of stem cell-derived colonies and the percentage of cell viability in the different groups. The presence of SSCs at different culture times was determined by immunochemistry, alkaline phosphatase, and xenotransplantation of SSCs into an azoospermic mouse model.
Results: The microenvironment of the feeder layer derived from the patient’s own Sertoli cells produced numerous (36.1±4) large colonies (213.2±17 µm) after 3 weeks of culture. However, the ratio of germ cell-specific expressions of Stra8 (2.3) and Vasa (2.2) was more than the pluripotency gene, Nanog (0.45) in SSCs cultured on the Sertoli cell layer of a healthy person. After xenotransplantation of human SSCs into the testis of an azoospermic mouse model, we observed that the cells grow on basement membrane of seminiferous tubules, which confirmed their nature.
Conclusion: SSCs could be co-cultured with Sertoli cells derived from healthy donors in order to overcome the arrest of spermatogenesis observed in the co-culture of SSCs with patient-derived Sertoli cells. The results of the present study indicated that spermatogenesis could possibly be resumed in cancer patients previously treated by chemotherapy and∕or radiotherapy.
Volume 19, Issue 2 (9-2016)
Abstract
Nowadays fertility and survival of generation highly considered in societies and male infertility raised as a major attitude for community health around the world. 14% of young couples in Europe have infertility problems. In Iranian couples the rate of infertility is higher than world standards and is about 20.2%. Hormonal factors, genetics and psychological problems cause 40-50 % of infertility in men. Since cancer patients are increasing progressively in industrialized societies and anti-cancer treatments highly eliminate the germ cells, so following cancer treatment reduce male fertility. Distinguish of primordial germ cells, recognition of their migration and also understanding of effective factors in differentiation of them can extended new ways for primary studies that follow production of germ cells from other cell sources like mesenchymal stem cells (MSC). Hence finding a way to distinguish germ cells from mesenchymal stem cells, preservation and proliferation of them in culture system can provide a base for spermatogenesis in vitro culture. Isolation and differentiation of germ cells from different cell sources such as umbilical cord using morphogens (Bone morphogenesis protein and Retinoic Acid) is an efficient method for infertility research. In this study some effective factors in differentiation of umbilical cord mesenchymal stem cells to germ cells has been investigated.
Volume 21, Issue 3 (Fall 2018)
Abstract
Introduction: Cancer is abnormal cell proliferation and uncontrolled cell growth. Carcinogenic agents cause DNA injury, depletion of tumor suppressor gene functions and it cause tumor forming and metastasis. Some carcinogenic agents related to cancer etiology are physical carcinogens such as ultra violet, chemical carcinogens such as chemical materials, cigarette smoke, unbalanced diet, job dependent factors, inheritance, hormones, metabolic factors and biologic agents especially some bacteria and viruses. Today’s most important treatment for cancer is chemotherapy that has many side effects and additionally cause to drug resistance. Some plants for years are known as reliable and excellent source of anticancer agents to develop anticancer drugs. Some of plants have preventive and therapeutic effects on cancer and some of them can decrease side effects of chemotherapy and radiotherapy and additionally are economic. This article reviewed the most important anticancer natural substances in the world and introduced the most important mechanisms of their effect.
Conclusion: In traditional medicine of the most countries have known many natural substances for a variety of cancers. Some of the most commonly known traditional anticancer materials in the world are Chinese rabdosia, polyphenolic flavonoids such as quercetin, Baicalensis Scutellaria, garlic, curcumin, and so on. Anticancer drug mechanisms of the most of these substances are related to antioxidant properties and inhibit the growth of their tumor cells. Many of these materials are traditionally used in different parts of the world.
Volume 22, Issue 1 (Winter 2018)
Abstract
Primordial germ cells (PGCs) are the specialized cells that are created from epiblast cells and after the migration differentiate into spermatogonial cells. Also, Spermatogonial cells differentiate into spermatids during the spermatogenesis process. Created disorders in each of these stages cause infertility, so the recognizing of the mechanism of these cells from the early stages of formation to the differentiation and investigating the effective factors in differentiation can be useful in the treatment of the infertile people. Today, the cultivation of spermatogonial cells and transplantation of these cells can be effective in the investigation of spermatogonial stem cell and the treatment of infertility. In this paper, the formation and migration of primordial germ cells, the spermatogenesis process and the effective factors in differentiation of spermatogonial stem cells are investigated.
Volume 22, Issue 1 (Winter 2018)
Abstract
Introduction: Due to increase of infertile couples, potential differentiation and proliferation of umbilical cord mesenchymal stem cells (MSCs) and bone marrow stem cells (BM-MSCs) was compared to find proper stem cells for differentiation into germ-like cells.
Materials & Methods: In this experimental study, isolated umbilical cord and bone marrow mesenchymal stem cells were treated by Retinoic acid (10-6M) and Sertoli cells condition medium. Viability percentage and the rate of proliferation (population doubling time) of cells was calculated in both groups. The number of colonies was evaluated in different days of culture, and finally the expression of and meiotic genes investigated by RT-PCR.
Findings: The viability percentage was higher in BM-MSCs group and the rate of proliferation of cells increased by elevating the passage number. The number of colonies in the bone marrow stem cells was significantly higher than that of the umbilical cord MSCs (p<0.05). In contrast, the expression of PLZF, OCT4 and SCP3 genes were detected in umbilical cord MSCs after 10 days of culture. However, in BM-MSC, the expression of PLZF and SCP3 genes was observed only after 15 days of culture.
Conclusion: It seems that the human umbilical MSCs higher differentiation potential for producing germ-like cells when compared to the Bone marrow stem cells. In contrast, the proliferation potential of BM-MSCs is greater than umbilical cord MSCs. This difference is probably due to secreted growth factors from these cells.
Volume 23, Issue 2 (summer 2023)
Abstract
Introduction
In developing countries, the shocks that enter the economy due to capital market fluctuations have more depth and durability. Because of the two-way connection between the stock market and the real sector of the economy and public attention to this market, examining the stock market shocks is of great importance. Therefore, the present study investigated the extreme fluctuations of the stock market index, which suspected the existence of bubbles. Timing of these bubbles in the market is one of the goals of this study, which was carried out by using the right-tailed unit root tests based on the augmented Dickey-Fuller test. A stock price bubble may be affected by monetary policy. This issue is influenced by the size of the bubble and the type and strength of the applied monetary policy. The impact of monetary policy fluctuations and especially interest rates on stock price bubbles is theoretically uncertain and should be determined empirically. Therefore, another goal of this study is to examine the effects of monetary policy shocks on the formation and timing of the stock market bubble.
Methodology
The method of Phillips et al. (2015) has been used to identify and time the stock market bubble. Galli and Gambeti model and TVP-SVAR method were also used to investigate the effect of monetary policy on the stock market bubble.
Results and Discussion
BSADF (Backward Supreme Augmented Dicky-Fuller) test has been used to determine the dates when the stock market had a bubble. According to this test, in three short periods, from July to September 2005, from April to May 2011, and from October to November 2018, the stock market behaved like a bubble. Regarding the impact of the interest rate shock on the stock market bubble, it can be said that the monetary expansion shock (decrease in the real interest rate) causes the bubble part of the stock price to become larger. In all periods, the response of the bubble part was positive, but over time, has increased, and since the beginning of the 2010s, its response to the shock of interest rate reduction has completely changed. The liquidity shock, also strengthens the size of the bubble. The amount of this influence has also increased greatly over time and has reached its peak in 2017 (the year of the formation of the price bubble in the stock market based on the BSADF test). Therefore, it can be claimed that the increase in the bubble part of the stock price was caused by a positive shock or an increase in liquidity. Regarding the effect of the credit shock on the stock market bubble, it can be said that credits has affected the fundamental part of the stock price, but it does not have much effect on the bubble part of the stock price. In fact, the increase in credits has caused the liquidity restrictions of economic enterprises to be removed and has an effect on their production and sales and finally on their profitability. Therefore, it is expected that with an increase in credits (positive credit shock), most of the fundamental part (current and future profitability) of companies will be affected.
Conclusion
During the last decade, the public attention to the stock market in Iran increased significantly. This issue caused the entry of new funds into this market, which was seen in the bubble-like behavior of the stock price index. In the conventional economic theory, the positive impact of expansionary monetary policies on the bubble is expected, but there are other theories that make the long-term impact of the monetary policy shock on the size of the bubble uncertain and dependent on factors such as the size of the bubble, the stability of the monetary policy, and the type of monetary tool. In order to solve this theoretical ambiguity, the effect of one of these cases, i.e., changing the monetary policy tool, on the stock price bubble was investigated. Before that, the existence of a bubble in the stock market had been checked. Regarding the impact of monetary shocks on the stock price bubble, according to the type of monetary policy instrument, the reaction of the stock price bubble has been different. Interest rate policy and liquidity have had a positive effect on the bubble, but credit policy has not had such an effect. In most of the developed economies, the interest rate change is the most powerful monetary policy tool, as a small change in it can have a large impact on the real sector of these economies. But in our country, according to the empirical findings of this article, the effect of liquidity on the stock market bubbles has been greater than the effect of changing the interest rates on it. This result is a proof of the dominance of liquidity over monetary policies in Iran.
Keywords: Monetary policy, interest rate, liquidity, stock market price bubble, Vector Autoregressive with Time Varying Parameter
JEL Classification: C22, E32, E44, G14
Volume 26, Issue 1 (1-2024)
Abstract
This research was conducted with the aim of designing a strategic extension-education theoretical model for agricultural waste management to sustain agricultural development in Mazandaran Province. The statistical population of this study included experts, gardeners, and farmers in Mazandaran Province, among whom 30 people were selected using the purposeful sampling method and snowball technique. A semi-structured interview was conducted to collect research data. The data collection process continued until the theoretical saturation level. A qualitative data analysis was performed using MAXQDA12 software. Analyzing this model showed that factors affecting agricultural waste generation consisted of five categories as, respectively, farming practice, market and transportation, processing procedures, agricultural and natural and support policies, based on their impact factors. In addition, 12 factors within these categories affected the establishment of agricultural waste management extension education were identified. Based on their impact factors in the model, these categories included class participation, food processing industry development and expansion, general knowledge and information about agricultural waste, appropriate farming practice education, educational workshop participation, farm visits, farmers and gardeners education, listening to the radio and TV educational programs, group discussion participation, transfer of new applied waste management technologies, and contact with agricultural extension agents, respectively. Therefore, it is highly recommended to put in action the theoretical model provided in this research for the sake of agricultural development in Mazandaran, Iran.
