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Showing 2 results for Rahaiee
Mahboobeh Zare, Nilofar Asadi, Somayeh Rahaiee, Mahmoud Kiani,
Volume 16, Issue 1 (12-2024)
Abstract
Cancer is one of the leading causes of mortality worldwide. this multifactorial disease characterized by complex molecular landscape and altered cell pathways that results in an abnormal cell growth. One of the recent strategies to combat cancer is application of phytochemicals. phytochemicals including phenolics, alkaloids, terpenoids, carotenoids, phytosterol, saponin and organosulfur compounds which play important roles in the prevention and treatment of cancer. The pharmacological use of phytochemicals compounds is frequently limited by their low bioavailability and solubility as they are mainly lipophilic compounds. The nanotechnological approach improves bioavailability, and inhences solubility. In the present review we aim to summarize challenges of phytochemical compounds in cancer treatment and the status of phytochemical based nanoformulations in improving the therapeutic response.
Volume 19, Issue 127 (September 2022)
Abstract
Chia seeds are considered as a rich source of bioactive and functional compounds. Due to the fact that bioactive compounds are unstable against environmental factors The stability of these compounds was important And encapsulation is a useful way to increase the stability of these compounds. In this study, nano-capsules of chia seed extract (CSE) with nano liposomes and basil seed gum (BSG) were produced and its physicochemical properties and release were investigated. nano-liposomes were first prepared using lecithin and different concentrations of CSE and then coated with three levels of BSG. The physicochemical properties and the CSE release from nano-capsules were examined. The lowest mean particle size (59.23 nm), low PDI index (0.328) and high encapsulation efficiency (80.06%) were observed in the Nano-capsules containing 0.5% CSE coated with 1.0% BSG (L0.5BSG1). Since the zeta potential of nano-capsules produced in this study was higher than ± 30 mV, so they had high stability. Based on the TEM images the L0.5BSG1 nano-capsules had spherical and irregular shape and low tendency to accumulate. The FTIR analyses showed physical interaction between nano-capsule components and also confirmed the presence of phenolic compounds in the nano-capsules. In terms of release rate in the gastric and intestinal simulated conditions, the CSE-loaded nano-capsules had a controlled release relative to free CSE. Finally, the results of this study demonstrated that L0.5BSG1 nano-capsules could possibly be used successfully in the pharmaceutical and food industries.
