Showing 7 results for Sabagh
R. Sabagh, A.a. Haddad-Mashadrizeh , S. Dolatabadi ,
Volume 10, Issue 2 (Spring 2019)
Abstract
Immunotoxins, as a critical approach for cancer therapy, have ability to induction death in cancerous cells based on specific ligands for targeting cancer-specific antigens and toxin domains in its context. Bearing in mind, discovery the cancer-specific antigens, as well as immunotoxin characterization for modeling based on linkers application, is a critical step for drugs design, which is considered in this study for ovarian cancer based on in-silico biology. The results of this study, led to the detection of 29 antigens with expression capacity on the surface of ovarian cancer cells, with the highest and specific expression associated with MAGE4 and CA125 antigens. Moreover, the 3D structure of MAGE4 was performed, and the pattern of its expression was determined to rely on HLA proteins. On the other hand, among connecting proteins to this antigen TRIM69 selected as the most effective ligand. Subsequently, the assembling between the domain of Corynebacterium diphtheria and this ligand with (GGGGS) 3 linker in 5 positions led to the creation of 50 models, with different quality and structure. However, among these models, S4 drug showed the best structure and function including binding affinity and immunogenicity after simulation in physiological condition. Generally, this result led to present the MAGE4 as a suitable candidate for immunotoxin development for ovarian cancer, as well as an effective immunotoxin which should be considered in an experimental condition.
Volume 11, Issue 4 (Fall 2023)
Abstract
Aims: Health literacy includes a range of critical skills that allow individuals to empower themselves to promote health behaviors. This study aimed to review the articles related to health literacy in the last 20 years and explain the factors associated with health literacy or predict it.
Information & Methods: This systematic review examined quantitative research articles published from 2002 to 2022 and indexed in Scopus, PubMed, and Web of Science databases. 887 articles were retrieved, and based on inclusion/exclusion criteria, 55 articles were reviewed.
Factors with the most frequent were reported and discussed. The role (prediction or association) was determined based on the highest frequency. The PRISMA 2009 framework was used to conduct a transparent process.
Findings: Younger people, white people, females, people with higher education levels, good social status, occupation, especially lifetime main occupations, higher individual income, higher knowledge level, and healthy people had high levels of health literacy. Also, the factors that had a significant relationship with health literacy (predictive or related) were different in patients and healthy people.
Conclusion: Health literacy includes various constructs and is related to different factors (as predictors or associated with health literacy). It may differ based on socio-economic and demographic characteristics in different communities.
Volume 12, Issue 1 (Winter 2024)
Abstract
Aims: Numerous and diverse tools have been designed and validated for measuring health literacy. The aim of this study was the validation and adaptation of the HeLIA instrument for measuring health literacy in thalassemia major patients in Iran.
Instrument & Methods: This is a cross-sectional study, and data collection was done from October to December 2022. The research population included patients with thalassemia major hospitalized at Shahid Baghaei 2 Hospital in Ahvaz. The statistical population was 300 people, and the sample size was 170. The pre-validation population included 50 patients and ten experts for validation. Reliability was calculated using Cronbach’s alpha (for internal consistency). The Kuder-Richardson's (KR) test checked the consistency between the questions. Using Kaiser-Meyer-Olkin (KMO) was the measure of sampling adequacy. The Pearson correlation coefficient was used in this study. Also, SPSS 24 and Amos 24 were used.
Findings: The HeLIA is valid based on face validity, content validity, and construct validity. Cronbach’s alpha was 0.891 and showed the validity of the tool. Explanatory factor analysis showed a model with four factors named “understanding,” “reading, access and evaluation,” “care measures,” and “decision and using,” which can explain 53.149% of health literacy variances. Also, IFI=0.823, CFI=0.816, NFI=0.713, and RMSEA=0.08 show the model's fitness, and, the KR21=0.89, indicated the reliability of the tool. Pearson’s correlation coefficient showed significant correlations between all factors.
Conclusion: The findings of this study confirm the validity and reliability of the HeLIA in thalassemia major patients in Iran.
Volume 16, Issue 96 (February 2020)
Abstract
Chitosan is a natural polymer that is typically extracted from the marine crustacean chitin shell and capable of film forming. Polyvinyl alcohol is a synthetic and biodegradable polymer that can be used in combination with natural polymers to improve structural properties. Chitosan nanoparticles were produced by ion gelation method and the nanoparticles with an average size of 69.92 nm and a zeta potential of + 30.3 mV were used for application in the composite films. After mixing different ratios of polyvinyl alcohol (P) with chitosan (C) (1: 3, 1: 1 and 3: 1), the resulting solutions with different ratios of nanoparticles (np) (0, 2, 4, 6) ml of chitosan gel In 100 ml of film forming solutions were mixed and glycerol was added to 25% w / w dry film powder and then poured into mold and dried in oven at 40 ° C. The results showed that increasing the ratio of polyvinyl alcohol and application of nanoparticles in polymer structure improved the physico-mechanical properties of the films. Fourier transform infrared spectroscopy results showed that some interactions have taken place between the polymer network and the nanoparticles. Thermogravimetric analysis results showed that the addition of nanoparticles slightly increased thermal stability of the polymers compared control samples without nanoparticles. Release results in the high-fat and low-fat food simulant showed that the release rate decreased with increasing polyvinyl alcohol ratio. Also, increasing the nanoparticle to np4 ratio decreased the release rate. The aim of this study was to determine the optimum ratio of two polymers and the amount of chitosan nanoparticles containing natural antioxidant catechin for use in food packaging.
Volume 18, Issue 72 (7-2021)
Abstract
Shahnameh is the most prominent epic work of Persian language and literature and one of the literary masterpieces of Iran and the world. Correction, description, critique and analysis of Shahnameh is one of the fields of study of Persian language and literature researchers. There have been many and valuable efforts in the field of correction of the Shahnameh text and its description. According to the Shahnameh researchers, the correction of the Shahnameh by Jalal Khaleghi Motlagh, along with the precise recording of other manuscripts in the footnote, is a complete and perfect correction in this filed. In addition to this correction, Shahnameh's photographic prints, scholars' access to other corrections of the Shahnameh, as well as commentaries on the Shahnameh are very helpful in opening up some difficulties. In the light of the foregoing efforts of the Shahnameh researchers, in this study i will indicate the suggestion to record and to give a meaning of the verse from the story of Forud based on San. Joseph's version, which he did not have this verse at the time of correcting and describing the Shahnameh. The author will attempt to review the correctors and commentators opinion about the so called verse and also by referring to manuscripts text, in-text evidences of the Shahnameh, out-text evidences of contemporary and near-Shahnameh texts and the sequence of verses in the context of the story propose their suggestion based on manuscripts and consequently the meaning and sense of the verse with the help of recordings and obtained evidences.
Volume 19, Issue 4 (7-2017)
Abstract
Defoliation is an important management practice of cotton production. Field experiments were conducted for exploring response of cotton to defoliant application times at various percentages of boll opening on seed cotton yield and fiber quality. Experiments were arranged in split-plot design with defoliation times (control, 40, 60, and 80% open boll) as the main plots and cultivars (hairy leaf, semi-smooth leaf, and smooth leaf) as subplots, with three replicates. The pooled results indicated that early application of harvest aid products significantly reduced seed cotton yield, boll number per plant, micronaire and fiber length. Significant reductions in seed cotton yield occurred with defoliant applications both prior to and after 60% open boll application timing. Application at 40% followed by boll opening had the maximum number of the green leaves remaining on the plant at 14, 21, and 28 days after treatments and a corresponding high trash content and high leaf grade. However, except for the leaf grade, the number of green leaves remaining on the plant after defoliation and the trash content, varietal differences were non-significant. Smooth leaf cultivar (SG 125) had the highest number of green leaves left on the plant after treatment (79.2) compared with hairy (71.9) and semi-smooth leaf (77.1) cultivars. It was concluded that cotton cultivars with varying levels of leaf hairiness impacted the defoliation efficacy of the harvest aid products.
Volume 22, Issue 3 (5-2022)
Abstract
Graphic Statics is a visual analysis and calculation method to find the type and amount of internal forces in structures, which achieves this importance away from computational difficulties and only with a geometric approach focused on two reciprocal diagrams of form and force. In this paper, arched trusses based on Warren type are analyzed using graphic statics. For this purpose, the parametric model of form and force diagrams were programmed in the Grasshopper parametric plugin. Parametrization has also provided the ability to find and analyze any different types of free-form trusses based on the type of warren truss. To measure the validity of the method and the accuracy of the algorithm written in the Grasshopper add-on, the numerical results obtained from several samples of arched trusses under different loads have been compared with the finite element computational method. The results of the validation simulations indicate the high accuracy and speed of the proposed algorithm.
