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Showing 2 results for Biomimetic
, , Shahab Faghihi,
Volume 4, Issue 1 (10-2013)
Abstract
The aim of this study is to investigate the relationship between the structure and function of an osteocalcin derived peptide on hydroxyapatite nanocrystal formation. For this purpose, , a natural motif sequence consisting of 13 amino acids present in the first helix of osteocalcin was selected based on its calcium binding ability and synthesized in both acidic and amidic forms using solid phase method. Circular dichroism (CD) and electron microscopy were performed to examine the structure and function of synthesized peptides. Moreover, the effect of these peptides on the viability of osteoblast cells was evaluated. Electron microscopy analysis showed the formation of plate-like HA nanocrystals in the presence of amidic peptide. In contrast, amorphous calcium phosphate was formed in the presence of acidic peptide. CD spectra analysis confirmed the random coil structure with lower molar elipticity for amidic peptide. In addition, the amidic peptide significantly increased the proliferation of osteoblast cells. It is concluded that increased bioactivity, which only occurred in amidic peptide is attributable to C-terminal amidation. It is also proposed that peptides with the ability to promote HA formation have the potential to be utilized in hard tissue regeneration high bioactivity and biocompatibility.
Volume 13, Issue 4 (1-2024)
Abstract
Companies have various strategies in front of them to meet their technological needs. In many cases, endogenous development of technology is not cost-effective and firms use other methods (both formal and informal) to transfer and acquire technology. Our studies show that so far no standard list of these methods has been provided in the literature and the existing lists have been formed based on the personal observations of researchers. Based on this, this research seeks to provide a standard typology of technology transfer and acquisition methods based on a theoretical framework. This study models a variety of methods of technology transfer and acquisition with interactions between particles with the biomimetic method, which is a structured method for inspiration from nature to solve human challenges. For this purpose, in the first step, "interactions between particles" - which are known and have specific types - have been chosen as the best counterpart that can model the technological relationships between companies. In the next step, the evidence needed to explain the main dimensions and elements of the research model (semantic relationships between the concepts and components of two phenomena in chemistry and management) is collected, and then a one-to-one correspondence is established between the elements of the research subject and the selected counterpart to obtain the final mapping. The modeling of this research shows the existence of 13 technological relationships. The ideas of this article can be the beginning of a path for the use of chemistry in human relations management issues.
