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Showing 3 results for Electrical Stimulation
M. Banimostafa Arab, S. Kushkestani, V. Mehdizadehfar, H. Sajedi,
Volume 10, Issue 3 (9-2019)
Abstract
Transtympanic Promontory Stimulation Test (TPST) has been suggested to be a useful tool in predicting the effectiveness of cochlear implant surgery. This test is helpful for patients with poor auditory neuron functioning and individuals with a long auditory deprivation. It can provide a way to find a correlation between the dynamic range of the auditory nerve with the electrical dynamic range of the cochlear implant and estimate sound perception. In this study, an electrical stimulation device is designed and constructed that can produce stimulation with specific features. The device has two parts, hardware, and software. Software is designed as a user interface which installed on PC and helps the user to do a lot of operations for creating a desired electrical stimulation easily utilizing software menus. The data are transferred via serial port and network to hardware and finally, the stimulation is done through an active electrode that located in auditory canal and a passive electrode that can be placed on the mastoid or forehead. To ensure the proper functioning of the device, electrical tests have been done in different conditions. The results are shown that currently generated in a constant load resistance is linear and independent of load resistance.
Volume 25, Issue 3 (4-2022)
Abstract
Novel antiepileptic drugs (AED) are now available. However, many epileptic patients still find the condition difficult to handle. Drug therapy does not work for about one-third of the cases and not all people who will benefit from surgery. The use of electric current as a treatment option has emerged since the late twentieth century. Inhibition of synapse activity is a way that low-frequency stimulation (LFS) prevents epileptic activity. It will enhance the endocytosis of AMPA-type glutamate receptors and activate calcineurin, thereby leading to long-term depression (LTD). High-frequency stimulation (HFS) also contributes to the control of epilepsy by increasing the membrane permeability of neurons. Nonetheless, the detailed mechanisms responsible for these effects are still unknown. More research is required to fine-tune electrical stimulation parameters and yield better results in epilepsy patient care.
Volume 26, Issue 2 (4-2023)
Abstract
Introduction Epilepsy is a common neurological disorder that affects millions of people worldwide. While there are many treatment options available, including drug and non-drug therapies, there is still a need for effective treatments that can help manage seizures.The present study aimed to investigate the intensity-dependent effects of mild electric foot stimulation on seizure intensity following pentylenetetrazol (PTZ)chemical kindling in rats.
Methods: Kindled seizures were induced in rats by repeated injections of PTZ. Twenty-seven male rats were randomly divided into three groups: kindling group, kindling group + 0.1 mA electrical stimulation, and kindling group + 0.01 mA electrical stimulation. Electrical stimulation was induced using an electric box equipped with steel rods following acquisition of kindled seizures. The intensity of the mild electric foot stimulation was either 0.1 or 0.01 mA depending on the tested group.
Results: The study found that while mild electric foot stimulation with intensity of 0. 1 mA had proconvulsive effects on PTZ-induced kindled rats, and
decreased the latency to the onset of stage 5 seizure (p<0.05), stimulation with
intensity of 0.01 mA did not have significant effects on seizure parameters.
Conclusion: Obtained results suggested that mild electric foot stimulation may have anticonvulsant effects, but only at certain intensity. This finding has important implications for future research into the use of mild electric foot stimulation as a treatment for epilepsy.
