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Showing 2 results for Electrochemical Sensor
Ali-Akbar Zare, Fatemeh Molaabasi, Hossein Naderi-Manesh,
Volume 15, Issue 1 (3-2023)
Abstract
Rapid and sensitive diagnosis of breast cancer, especially in the early stages of its formation, is very important. One of the methods of detecting cancer cells is the use of electrochemical sensors. Here, a new nanocomposite including an organic metal framework and silver nanoclusters are used. The resulting nanocomposite can be used as a scaffold to attach antibodies for the detection of HER2-positive cells. In the final nanocomposite structure, silver nanoclusters are placed in the internal cavities of the metal-organic framework, leading to strong electron transport, good biocompatibility, and high electrochemical activity. Our results showed that the designed electrochemical sensor has a high sensitivity in identifying HER2 positive cells, with a detection limit of 3 cells and a linear range of 100 to 5000 cells/ml. Also, the investigations showed that the introduced sensor has stability, good selectivity and acceptable application. The proposed strategy for the development of sensors based on metal-organic frameworks provides a promising approach for early detection of cancer markers and living cancer cells.
Volume 19, Issue 126 (8-2022)
Abstract
Additives analysis plays important role in food quality control and has a great impact on public health. Therefore, rapid detection of these compounds in food samples is important in food safety. In this study, reduced graphene oxide /Fe3O4 nanocomposite (rG-Fe3O4-NC) was synthesized in the presence of sour lemon peel extract as a reducer and stabilizer agent in aqueous solution. For the first time multivariate optimization based on rotatable central composite design (RCCD) coupled with response surface methodology (RSM) was used to optimize effective experimental variables for fabrication of electrode. An experimental design has been used to examine and optimize the impacts of diverse experimental parameters like the pH and concentration of the nanocomposite in rG-Fe3O4-NC. The optimal conditions were pH: 6 and the concentration of the nanocomposite: 8%. The synthesized nanocomposites were characterized by TEM and XRD techniques. The rGO modified carbon paste electrode (rG-Fe3O4-NC/CPE) was used as a highly sensitive electrochemical sensor for the detection of vanillin. Interference of vitamin B2, methionine, valine, glycine and KBR, KCl and glucose were checked in the presence of 25 µM vanillin at surface of rG-Fe3O4-NC/CPE with acceptable error 5%. Results confirmed that 500-folde of above compounds have not any important interference in monitoring process of 25 µM vanillin. The vanillin sensor showed linear range between 01 nM – 250 μM and a low detection limit of 0.3 nM. Finally, the rG-Fe3O4-NC/CPE was successfully used for determining vanillin in food samples. Therefore, this sensor can be used in food industry to the online determination of vanillin in flavored milks and ice cream.
