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We present a method to predict the flexible and rigid regions based on sequence. We use the free energy of two consequent amino acids to define a factor for distinguishing flexible regions from the rigid ones. Using statistical analysis of this free energy, we assign a normalized number between zero to one hundred which we call it flexibility number. Taking the effects of up to four neighbors of an amino acid, into account, resulted in an efficient prediction of flexible and rigid regions of a protein.

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Considering the vast changes in different aspects of life and various ways of earning livelihood, flexibility in contemporary housing design can be regarded as an appropriate solution in order to prevent from discreteness in interactions within the society and environment and among people. That is because a residence must be designed according to the changing needs of modern human. Traditional houses in Iran have already contained this concept, in modern era however, such viewpoint towards housing cannot be seen so often. Flexibility refers to the idea of adaptation throughout the time. Therefore it can be said that a flexible settlement is a house that can be adapted with the needs of the users and will lead to understanding the users’ expected demands with their own cooperation. Peoples’ cooperation in this process will increase the possibility of adaptation of housing with their needs which will eventually increase the general satisfaction of the housing. This research discusses the issue of flexibility and the related concepts in the field of housing with emphasis on some residential projects. Every settlement is depended on its user and the ground for its adaptation. Therefore, in terms of general design, we can say that settlement is dependent on both the environment and the user. Since human beings normally demand variety and  monotonous environmental conditions make human beings unsatisfied and bored; they usually have a favorable and positive view towards changes in their living environment. These varieties can range from some minor changes up to basic ones such as a change in the residential house itself. Flexibility in architectural design indicates variety. Such variety includes the possibility of adjustment and compatibility of a residential unit throughout time. It will eventually lead the building to show new varieties of its own. In order to demonstrate flexibility, the architects have to put the probable needs of the users into consideration in the process of designing. In other words, a “long-term thought” is required in designing.Flexibility in housing can be investigated from two points of views: first, from users’ point of view and secondly the innovative construction. Designing consists of four main issues: (1) structural system; (2) servicing spaces; (3) architectural design; and (4) facilities for environmental flexibility. The present study tries to express the concept of flexibility as a “new form of challenging architecture”. This is done using some examples and instances. From such viewpoint, the goal this study tries to attain is to survey the limitations and boundaries of flexible designing. This is done by analyzing the selected items. This way, the architect can turn flexibility into an opportunity and produce creative options in his/her work and design. The present study was conducted using library-based method and case study with the aim of studying and discussing the conceptual and operational grounds of housing design in different countries. The structure and main framework of the present study stands on the idea that flexibility can be used for  housing development in all eras and periods as a general concept and includes different types itself.

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Work-related Musculoskeletal Disorders (WMD) are a common health related problem throughout the world. The aim of this study was to evaluate the effect of hydrotherapy training on health, function, motion, and occupational performance of the police personnel in Iran.
In this before/after prospective study, 30 participants were selected purposefully and divided into two experimental (n = 15) and control groups randomly (n = 15). The 8-week hydrotherapy training program was just assigned for intervention. The occupational performance and physical fitness tests, Health related Quality of Life (HRQoL) questionnaire and Visual analog Scale (VAS) were measured for both groups before and after intervention. data were analyzed through SPSS 16

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The subject of this article is to study the factors and criteria of urban street desirability and citizens' expectations from them. The problem of research is the lack of accurate knowledge of the components of urban street utility in its various sequences. The theoretical proposition of the research is that the existence of quality in the physical, spatial, semantic-symbolic and activity-social components leads to vitality, memory, safety and flexibility as dimensions of citizens' expectations of the urban street. . The research method of the article includes descriptive-analytical and survey methods. Data collection method Interview is an open and semi-structured questionnaire. The statistical population of citizens is three sequences from Valiasr Street.
The results of the research show that vitality and memory play an important role in meeting the expectations of citizens from the city street. The two dimensions of flexibility and safety play a lesser role than these other two dimensions. The proximity of the importance of the four components leads to greater desirability. For the desirability of an urban street, the role of physical, spatial, semantic and activity components is very different according to the nature of the street sequence, but the effectiveness of all four components in creating desirability and creating a unique street character is very important. Physical and spatial components lead to greater vitality and safety, and semantic and activity components lead to greater memory and flexibility.

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Designing complex subway station and mixing them with crisis management provides an opportunity to understand multi-functional of station spaces. This article seeks to reduce vulnerabilities in the analysis subway stations measures to be considered as temporary accommodation in an emergencies and provide a safe space research questions inclusive weather do you have ability to the performance is also, in addition to its roles as station for transport and cultural and commercial complex; in critical condition become to temporary housing? Or what factors effect on flexibility of architectural complex subway? We have very good station complex in our country. A station complex itself consists of several levels of services areas include entertainment and office. This type of sorting and spatial layout is designed based on the needs. But in this paper we discussed bout benefits of this wide space and advantages of all the facilities and equipment in emergencies. Developing countries, including Iran, in addition to being more prone to accidents and natural disasters than other communities, total human casualties and property damage in case of accident these communities are heavier. To prevent the occurrence, planning to rescue damaged area and temporary accommodation, all communities need new Disaster Management. In the present study we have tried through a multi-functional and flexible design, the central station with the highest integrity economic, social and environmental be prepared to deal with the sudden crises. Despite the unexpected event and the space subway stations is located in the basement created a good spaces for sheltering people affected. Theoretical Framework of research was formed on professional background. Description of the research subjects are used to identify a type of descriptive research. They checked through classified questions by the nature of the condition or a relationship between phenomena. This study uses for recognition of flexible spaces with different activities, after studying previous research, analysis and identification of deficiencies and issues that the extent of the subject matter. Factors were identified and then among them some of the most important factors affecting the enhanced versatility stations and related elements are removed and in the form of a questionnaire was developed. Considering that the present selective approach of the Delphi Survey. These questionnaires gave to professionals and experts in related field to examine their views on this issue answered questions. At the end of the questionnaire they provided the new classification according to their own idea. The thirteen components shaped on the form of a questionnaire. The flexibility of components and elements were created in the form of a table, then each component is associated with a short description and an example and then its influence were examined on the subway stations the fifty questionnaires were prepared and given to fifty experts. After one week about forty persons answered. Finally through analyzing these answers with the software SPSS defined two factors (Adaptation) and (Convertible) have the most effect on multi-functional design. Discuss about flexible architecture used in most developing countries. Use the subway as one of the most important infra structure of transport industry. And different countries follow the various purposes about construction and expansion of the system based on their political and socio-economic strategy and structure. In this research, urban transportation industry used toward protection, facilitating crisis management and reduce potential vulnerabilities and providing satisfaction in critical and noncritical periods. Following the development of the industry in the transportation and services the most of countries used of subway station as space towards temporary accommodation with the aim of maintaining and relief protection. On the other, stations being able to protect of people and providing essential supplies for certain time periods at a critical time. These information is done based on limited studies are available. One of deficiency in new architecture is lack of planning toward multi-purpose use. In the other word we can use from the facilities and equipment for temporary accommodation. Becausepeople take refuge the subway station unconsciously, In this regard in many countries subway stations is used as a shelter space. The main issue in this research is multi-functional and flexible design for example station while there are main function and accessories (transportation and provide daily needs), another function will have to meet the needs of citizens in a secure environment. These views with the aim of identify a plan to solve the unpredictable problems and issues in organization critical and methods to reduce the vulnerability of disaster, including recognition of the six stages of crisis management planning. Planning, forecasting, equipment, coordination, implementation, analysis, documentation and temporary accommodation, and how to solve the crisis management in 3 section including of identification, decision and evaluation of temporary emergency measures and consequence of after crisis, including the reconstruction in low-risk areas, construction of building according to the rules of retrofitting and flexible designing of the building and cities in the faces of crisis. Multi-purpose in architecture while has many advantages, there is a little attention has been paid. The research studies began with introduction includes the purpose and expanse of information about the main problem of the research. After classifying articles, books and theses and noted the main provisions of the existing theories, the case study was cleared. This research began with the most general resources and ended with the most relevant resources. A review of existing knowledge and to clarify the deficiencies found the concepts to understood multi-purpose architecture. After classifying component based on the measure of affectively, these components were described. These categories gave to the expert. In this time adaptation was priority. In the other word the flexible space will have greater flexibility and create the space, that provide needs of travelers and transport, facilities, crisis management, reducing vulnerabilities and satisfaction while helping temporary accommodation. In according to assumption of this research, if complex station designed multi-purpose and considerate required spaces for critical conditions can be held accountable as a temporary accommodation and components such as versatility and consistent spatial have a high impact on flexibility of architectural complexes.

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Abstract: The experimental study of structural vibration is often performed to determine the modal parameters of a structure or to verify the theoretical models and predictions. The first phase of this research involved the experimental determination of the modal properties of a rectangular steel tank with different levels of water. The natural frequencies obtained from the experiments were compared to those calculated by the analytical models. In the second phase, a procedure for computing hydrodynamic pressures in rectangular tanks is proposed. This procedure considers the effect of tank wall flexibility in determining the hydrodynamic pressures produced by the impulsive response. Based on a two-dimensional model of the tank wall, a dynamic time-history analysis was carried out. The results were compared with other models based on the current design practice codes and standards, which use a lumped mass approach. The comparison shows that, in most cases, the lumped mass approach overestimates the base shear. The effect of wall flexibility on wall displacements and base shears are also discussed.

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Firms in many industries rely on knowledge generated outside of the firm as an input to their own research and development. The ability to exploit knowledge that exists outside the boundary of the firm is calld Absorptive Capacity. Cohen and Levinthal defined AC as ‘‘the ability of a firm to recognize the value of new and external knowledge, assimilate it, and apply it to commercial ends’’. They argued that AC is an organizational learning concept and the cumulative effect of continuous learning. However, this definition deals primarily with external knowledge. Implicit in the definition is the notion that firms are aware of internal information and have access to it. In some cases, organizations may not be aware or have access to their existing knowledge, especially tacit knowledge that can only be communicated by direct social interaction.Thus, a network of formal and informal communication linkages are necessary for the internal diffusion of new knowledge and technology. We employed a social theory of absorptive capacity and investigated its affect on innovaton and fliexibility in firm. On the other hand, we investigated the effect of intersubjectivity on absorptive capacity . To illustrate the links, the present study tested the hypothesis by structural equation, applied to a large sample (n=619). The results indicated a strong, positive and direct relation among intersubjectivity, absorptive capacity innovation and flexibility.

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Aims: In the past years, the increase in economic pressures and the shrinking of families and the motivation to live a simple life have caused an increase in the demand for small-scale houses. The purpose of this research is to identify the framework and ranking of flexibility components that can be effective in small-scale housing.

Methods: In this research, using the descriptive-analytical method, the effective components in the design of flexible small-scale houses were identified and the conceptual framework of the research was confirmed using the Delphi method. Then, using the survey method, these components were ranked in the 10th district of Isfahan through Shannon's entropy test. The statistical population includes three groups of experts, architectural experts and the public, whose opinions have been compared and analyzed using comparative analogy.

Findings: The research findings show that the components that are important from the point of view of all three groups include: multi-functional spaces, mezzanine spaces, adaptable facade with variable uses, use of shallow plans with rectangular geometry, movable furniture according to ergonomics and movable partitions according to It is ergonomic.

Conclusion: In the end, it can be concluded that among the identified components, several components such as partitions and movable furniture are compatible with human ergonomics and adaptable view, and modern technology is an important tool to achieve them.
 

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Flexible members such as solar panels of robotic systems during a maneuver may get stimulated and vibrate. ‎Therefore, such vibrations will cause some oscillatory disturbance forces on the moving base and manipulated ‎object, which in turn produces error in the position and speed of the manipulating end-effectors, which should be ‎prevented. In this paper, a new control algorithm for an object manipulation task by a wheeled mobile robotic ‎system with flexible members is proposed. To this end, a new dynamics modelling approach for control ‎implementations on compounded rigid-flexible multi-body systems is introduced. Then, based on a designed ‎path/trajectory for a wheeled mobile robotic system, an Adaptive Hybrid Suppression Control (AHSC) is proposed ‎to perform an object manipulation task by such complicated rigid-flexible multi-body systems. Finally, a wheeled ‎mobile robotic system is simulated which contains two manipulators, and a rotating antenna and a camera as its ‎third and fourth arms, appended with two solar panels as has been proposed for space explorations. Obtained ‎results reveal the merits of the proposed AHSC algorithm which will be discussed.‎

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Aim: Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein that plays an important role in regulating cell survival, proliferation, differentiation, migration, inflammation, and modulating the immune system. The FK domain in FSTL1 has 10 conserved cysteine residues that form 5 disulfide bonds. Despite extensive studies on the function of FSTL1, limited structural information is available about this biologically important molecule.
Materials and Methods:Using the SWISS-MODEL server and using the crystal structure of the FK domain of the mouse FSTL1 protein with the code (PDB: 6jzw) as a template, structural models of the FK domain of the human FSTL1 protein were prepared. In the next step, the resulting structures were checked using Swiss-PDB Viewer 4.10, Chimera 1.12 software, Ramachandaran diagram and PDBSUM server, in terms of the distance between two cysteine residues, the modeling error range, and the formation of disulfide bonds. Molecular dynamics simulations were performed using the AMBER software package with the ff14SB force field.
Results: The results showed that the FK domain without disulfide bond has root mean square deviations (RMSD) and root mean square fluctuations (RMSF), higher than the native FK domain. In addition, the radius of gyration in domain without disulfide bonds is significantly lower than that of native FK domain. The results show that the disulfide bonds of the FK domain play a role in the stability of the structural folding of the FK domain and the removal of these bonds increases the structural flexibility of this domain.
 

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 Scheduling plays an important role in the development and success of the project; this has always been one of the main issues considered in operations and management science researches. Another reason for the focus of much research into it is the difficult nature of this problem. Therefore, special techniques and methods have been proposed to solve this problem. On the other hand, in order to intensify sanctions on foreign delaying projects, timely completion of projects has been accelerated. Therefore, attention to project robustness subject to project managements. In this article, a real issue is scheduled for a robust scheduling model of a refinery project. Since project scheduling has resource constraints such NP-Hard problems, simulated annealing algorithm was proposed to solve this problem. In order to validate the model, 4 problems with small size were chosen and the solutions obtained by the proposed algorithms were compared with the exact solution obtained by Lingo8 software. The results showed that the proposed algorithm is efficient and convergent to the optimal solution.

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The modern business environment is constantly changing, and manage this change to adapt to a future of uncertainties is a challenge that necessitates supply chain flexibility. We introduce a method for measuring flexibility based on gray system. For this purpose, the flexibility of Alpha Automobile Company that operates in Iran's automobile industry has been measured. The results suggested that sourcing limitations and Distribution problems are the most serious vulnerabilities that threaten Alpha Automobile Company. Therefore, the company must plan to improve its flexibility by selecting the appropriate set of capabilities. Moreover, effectiveness , supply flexibility and flexibility in order fulfillment were identified as three important capabilities of Alpha Automobile Company. Keywords: Flexibility; Gray system; Vulnerabilities; Capabilities The modern business environment is constantly changing, and manage this change to adapt to a future of uncertainties is a challenge that necessitates supply chain flexibility. We introduce a method for measuring flexibility based on gray system. For this purpose, the flexibility of Alpha Automobile Company that operates in Iran's automobile industry has been measured. The results suggested that sourcing limitations and Distribution problems are the most serious vulnerabilities that threaten Alpha Automobile Company. Therefore, the company must plan to improve its flexibility by selecting the appropriate set of capabilities. Moreover, effectiveness , supply flexibility and flexibility in order fulfillment were identified as three important capabilities of Alpha Automobile Company. Keywords: Flexibility; Gray system; Vulnerabilities; Capabilities

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This paper aims to identify effective networking human resource practices for managers and its effects on firm performance by analyzing strategic flexibility and environmental condition. Also, this paper has been completed based on a combinational approach and an expletory- explanation study. Data gathering tools in first step was semi structure interviews with 12 human resource managers in digital industry firms and leather industry. Purposive sampling and a thematic analysis conducted to identify networking human resource practices. At the second step 29 questions questionnaire used for measuring relationship among variables. Statistical population in quantitative step consist of 810 managers and supervisors of considered companies. Statistical sample were selected for each class according to random access method. Based on the results of thematic analyses, the most effective networking human resources practices were detected as training and learning, talent management, performance evaluation, financial and non-financial incentives. Results of structural modeling confirmed the effect of considered theme on strategic flexibility and firm performance. Other findings indicated that by using these practices in firms with environmental turbulence and via increasing strategies flexibility firm performance are affected indirectly.  Focusing  on  these practices in firms with environmental sustainability, improve performance directly by committing on existing strategies. Comparing result between firms confirm the moderate role of environmental condition in research model.

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Civil structures inevitably undergo damage over time due to various reasons such as environmental changes, material aging, load variations, and insufficient maintenance. Monitoring these structures, especially aging ones, is crucial to detect damage early on and implement suitable retrofitting measures, ensuring their continued safe and reliable operation without unexpected failures. Consequently, there has been significant research in this field, focusing on damage detection in both simple and complex structures. Health monitoring of highway bridges is essential for achieving a reliable transportation system. The vibration-based damage detection method uses changes in the vibrational properties of structures to detect damages and ensure a healthy state. In this study, the absolute value of the modal flexibility damage index and the modal strain energy damage index simultaneously are utilized to prevent unsafe decisions.
These absolute values of modal strain energy and flexibility damage indexes are utilized as the bases for training deep neural networks (DNNs). These indexes are applied to provide safe decisions and reliable damage evaluation in steel girder of the highway bridges. The convolution neural network (CNN) is utilized for damage quantification estimation. The CNN is one of the deep learning models that can currently be applied in 2D dominant approaches, such as pattern recognition and speech recognition. In addition, these networks can utilize the 1D time domain and vibrational signal data via the convolutional layer. The initial stage of CNN model comprises combined convolutional and pooling layers that apply different filters to extract features. Following this, fully connected layers, similar to a hidden layer of a multilayer perceptron are incorporated. Ultimately, these layers are classified together with a softmax layer. The convolution layer acts as a filter that convolutes the input layer with a set of weights, adding bias and applying an activation function to the outcome. Gradient descent momentum methods (SGDM) can be employed to optimize the parameters in CNN network architecture. SGDM estimates the gradient with high velocity in any dimension. This method mitigates issues such as jittering and saddle points by utilizing high-velocity inconsistent gradient dimensions and the SGD gradients, respectively. Additionally, when the Current gradient approaches zero, the SGDM provides some momentum.
The convolution neural network is trained to utilize damage indexes obtained from numerical simulation of the validated finite element model of the bridge. The damage indexes as the inputs for the neural network, which are achieved from different damage scenarios. Once network training and validation are completed, a well-trained neural network is used to detect, localize, and quantify the intensity of unknown damages. The proposed method overcomes previous damage detection problems such as false positive indications, the unreliability of a single damage index, and insufficient precision in determining the intensity.  The results revealed that the presented method, based on the dual updated damage indexes and CNN, practically and accurately identified unspecified single damages' location and severity in multi-span beams. The new training method of deep neural network systems overcomes some shortcomings in ANN. Moreever, this deep neural network training scheme can reduce the need for huge amounts of input data and enhance the accuracy of network training. The method is capable in predicting single damage scenarios in steel beam.