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In the Magnetically Assisted Chemical Separation (MACS) process, tiny ferromagnetic particles coated with solvent extractant are used to selectively separate radionuclides and hazardous metals from aqueous waste streams. The contaminant-loaded particles are then recovered from the waste solutions using a magnetic field. In the present study, Cyanex272 or C272 (bis (2,4,4-trimethylpentyl) phosphinic acid) coated magnetic particles are being evaluated for the possible application in the extraction of Uranium (VI) from nuclear waste streams. The uptake behaviour of U(VI) from nitric acid solutions was investigated by batch studies.
Adsorption of uranium (VI) from aqueous solution onto adsorbent was investigated in a batch system. Adsorption isotherm and adsorption kinetic studies of uranium (VI) onto nanoparticles coated Cyanex272 were carried out in a batch system. The factors influencing uranium (VI) adsorption were investigated and described in detail, as a function of the parameters such as initial pH value, contact time, adsorbent mass, and initial uranium (VI) concentration. Magnetically Assisted Chemical Separation (MACS) process adsorbent showed best results for the fast adsorption of U (VI) from aqueous solution at aqueous phase acidity value of 0.5 molar. In addition, more than 80% of U (VI) was removed within the first 2 hours, and the time required to achieve the adsorption equilibrium was only 140 minutes. Langmuir and Frendlich adsorption models were used for the mathematical description of the adsorption equilibrium. Equilibrium data agreed very well with the Langmuir model, with a maximum adsorption capacity of 48 mg.g^-1. Adsorption kinetics data were tested using pseudo-first-order, pseudo-second-order and intra-particle diffusion models. Kinetic studies showed that the adsorption followed a pseudo-second-order kinetic model, indicating that the chemical adsorption was the rate-limiting step.
 

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Aim: Most scientists are trying to treat cancer, and in this regard were produced numerous anticancer drugs, that adverse effects on non-target tissue. To overcome this, drugs freight to magnetic nanoparticles Chitosan and its carboxymethyl secondary coumpands are biopolymers that are non-toxic, biodegradable therefore found applications in biomedical field. We explain here that glycerol monooleate covered magnetic nanoparticles (GMO-MNPs) capable of transporting hydrophobic anticancer drugs. Method: In the present study, we have expanded 5-fluorouracil (5-FU) that loaded on chitosan MNPs for targeted cancer therapy. Results: The modified nano-adsorbent was then characterized by Fourier Infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), elemental analysis of CHN (9) and thermal weighing analysis (TGA). Lab conditions such as pH, contact time were optimized. To analyze the structure of the sample, X-ray diffraction spectroscopy was used to investigate the magnetic properties of the nanosized particles synthesized by the magnetometer and to detect the phase type formed on the monolayer glycerol matrix network using a polarizing light microscope. Also, the study showed essential oil release in the external environment of 90% for 30 hours. Conclusion: The optimized magnetic nanoparticles according to SEM image, exhibited segregated nanoparticles with sub-spherical smooth morphology and also the high thermal stability of 5-Fluorouracil nanoparticles which indicated a well-established structure of nanoparticles.

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Abstract
Research Subject: Breast cancer is one of the most common cancer in the world with the highest mortality rate in women. Chemotherapy is the typical therapy for the cancer. However, it has side effects due to damage to healthy cells. Targeted drug delivery by nano carriers to the cancerous cells reduces the toxic side effects on normal cells. Serum albumin is a widely used drug carrier because of its availability, ease of preparation, and binding ability to various ligands. Attachment of iron oxide nanoparticles to albumin can control their distribution by applying an external magnetic field.
Research Approach: In this study, albumin nanoparticles attached to superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized and loaded with 5-Fluorouracil (5-FU) anticancer drug by using the desolvation technique. The produced nanoparticles were characterized in terms of size, surface charge, and drug entrapment, by dynamic light scattering (DLS) and UV-Vis spectrophotometry. The cytotoxic effects of 5FU-loaded magnetic albumin nanoparticles and free 5FU on MCF7 cells were evaluated with the MTT assay. The internalization of nanoparticles in MCF-7 cells was confirmed by Prussian blue staining. In the end, the effects of nanoparticles on cell cycle and apoptosis were evaluated by flow cytometry using propidium iodide.
Main Results: The mean particle size and zeta potential of 5FU loaded albumin nanoparticles and albumin magnetic nanoparticles were 220 nm, -25.8 mV, and 221 nm, -28 mV respectively. Drug entrapment efficiency and drug loading efficiency were also, 20%, 1%, and 15.8%, and 0.06% for albumin nanoparticles and magnetic albumin nanoparticles in turn. The drug-loaded magnetic albumin nanoparticles showed higher cytotoxicity than the free drug on MCF-7 cells. The flow cytometry cell cycle analysis showed more cytotoxicity of albumin nanoparticles in comparison with other groups. According to these results, it can be said that 5-FU loaded magnetic albumin nanoparticles were more effective and deserve further studies in the cancer treatment.
Keywords: Albumin magnetic nanoparticles, 5-fluorouracil, targeted drug delivery, MCF-7 cell line

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Research Subject: In this study, Thiourea-functionalized super-paramagnetic nanoparticles were used as a heterogeneous catalyst in the Petasis-Borono Mannich reaction.
Research approach: In the first stage of this study, Fe₃O₄@SiO₂ nanoparticles were synthesized as spherical core-shell nanoparticles such that Fe₃O₄ particles were considered as the core. Then in the next step, the characteristics of surface functional groups, crystal structure, magnetic properties, size and surface appearance of nanoparticles and the process of functionalizing the structure in layers, using infrared spectroscopy (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) were examined, identified and analyzed. Then, to evaluate the efficiency of the structure, it was used as a catalyst in the Borono-Mannich reaction of potassium potash. Infrared spectroscopy (FT-IR) and hydrogen nuclear magnetic resonance spectroscopy (HNMR) were used to investigate the structure of the products.
Main results: The IR spectroscopy results showed that the peaks appearing in 568 cm^-1 and 670 cm^-1 were related to iron-oxygen bond, the peaks in 1092 and 800-950 cm^-1 were related to silicon-oxygen bond, which indicates the formation of silicon layer on nanomagnetic particles and the validity of the reaction products. The results also showed that the amount of saturated magnetite in about 23 emu/g increased with increasing complex ligand. X-ray diffraction analysis showed that the index peaks of (2θ= 21.25˚, 37.29˚, 43.73˚, 52.56˚, 65.09˚, 69.73˚, 76.81˚) were realized and for certainty of the formation of the desired magnetic nanoparticles in crystalline phase were used. The results of SEM analysis showed the structure of nanoparticles in a spherical shape and EDX analysis confirmed the presence of elements in the structure which included sulfur. Also, the thermogravimetric analysis index showed approximately 7% decomposition coefficient. The first, second and third decomposition were observed 1% by weight (60°C), 5% by weight (200 to 300°C) and 1% by weight (350 to 700° C), respectively. The highest yield of 68% was measured with 40 mg catalyst in acetonitrile. The structure of thiourea was properly stabilized in a magnetic nanocatalyst.

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In recent years, many studies have been performed on for use in various of science. The proper design and synthesis of these has a direct impact on their -chemical properties and their applications, especially in the field of biological sciences. There are several methods for magnetic synthesis. One of the simplest and most efficient methods for synthesis of magnetic is a chemical co-precipitation method, but of magnetic is one of the limitations of this method. In this study, various protocols for the synthesis of magnetic by co-precipitation method and silica coating of magnetic were performed and the effect of different factors such as the type of alkaline compound, the use of , temperature and in dispersion, aggregation of magnetic nanoparticles and their stability in aqueous solutions was investigated. Finally, a simple and reproducible protocol for magnetic synthesis with appropriate size distribution and high dispersion in aqueous solutions was optimized for use in biological applications.

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Cancer is a disease that begins with abnormal proliferation of cells. Genes inside each cell has issued the necessary orders to the cell. Sometimes these commands in a cell are undefined and cell has abnormal behavior and after a while some of abnormal cells can circulate in blood or change into tumors. In A numerical study was carried out on the heating effect of magnetic nanoparticles used in hyperthermia with the goal of attaining a desired rise of temperature at a particular point of location of the tumor situated inside the muscle. A numerical scheme is proposed to solve the bioheat transfer problem in a two zone tissue in spherical geometry with blood perfusion and metabolism. The analytical solution evidences the accuracy of the numerical scheme and examines the results in the literature. Bio-heat equation is used to predict the temperature rise in term of characteristics of the magnetic nanoparticles, applied magnetic field and the tissue. Results show that the strength of applied AC magnetic field has the minor effect, the volume fraction and the frequency of applied AC magnetic field has moderate effect and the diameter of nanoparticles has the major effect on the temperature rise. among materials investigated in this study, FePt has the most pronounced effect. Also, the temperature rise for a position- independent perfusion rate is larger than that found for a position-dependent perfusion rate. Likewise, the temperature rise for a temperature-dependent metabolism rate is larger than that found for a temperature-independent metabolism rate.

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Gene delivery using the force of a magnetic field is called magnetofection. The purpose of this study is the synthesis and characterization of magnetic iron oxide nanoparticles (Fe₃O₄) as the core of the transfer agent and to investigate the effect of alternating magnetic field on transfection efficiency. For this purpose, the first magnetic nanoparticles (MNP) were synthesized by coprecipitation method. The magnetic properties of the synthesized MNP were investigated by vibrating sample magnetometer (VSM), appearance characteristics, and zeta potential of the synthesized particles were evaluated  using transmission electron microscopy (TEM) and dynamic light scattering (DLS). Then, using magnetic nanoparticles (MNP), polyethylene imine (PEI) and plasmid DNA containing luciferase reporter gene (pDNA), PEI-pDNA binary complex and MNP-PEI-pDNA ternary complex were synthesized. The complexes were evaluated using DLS and gel retardation techniques. The results of DLS and gel retardation technique showed that the complexes have a suitable surface charge and polyethyleneimine is well joined to pDNA and neutralized its negative charge. Finaly, human breast cancer cell lines (MCF-7) and Hek293T cells were transfected by ternary complex in the presence of 50 Hz alternating magnetic field. Cell viability was measured using the MTT test. The obtained results showed that the transfection efficiency in the cells that were transfected with the ternary complex in the presence of alternating magnetic field increased significantly compared to the control group, without any additional toxicity (P ≤ 0.05).
 

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This numerical study forced convective heat transfer ferrofluid within a circular copper tube includes portions of the electromagnetic isolation under an alternating magnetic field is performed. Laminar flow through a tube under uniform and thermal flux passes. Intensifying transfer of particles and velocity increase in the boundary layer using nanoparticles to increase the effect of magnetic field onto more heat transfer, the main goal is. Convection regimens resulting from complex interactions between magnetic nanoparticles were studied under different conditions, with the concentration and volume of different the heat transfer process under different frequencies of the applied magnetic field were studied. Magnetic field effects on the convective heat transfer coefficient at different Reynolds numbers and volume percentages have been studied. Also when the electromagnetic is insulated pipe parts of have been studied and have been compared with the modes without insulation. Increase the frequency and volume fraction of magnetic field, resulting in increased heat transfer were better. Magnetic field at low Reynolds numbers have shown a greater impact. For prove the numerical results evaluated in this research work has been studied experimentally. The results showed that the modeling data were in very good agreement with experimental data.

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In this paper, drug coated magnetic nanoparticle delivery is numerically studied. Specific part of right foot vessel connected to the abdominal aorta is considered as target tissue. Single wire is applied as magnetic source. Buongiorno’s two-phase model is modified by adding the magnetophoresis term to the volume fraction transport equation. Governing unsteady equations with ferrohydrodynamics Kelvin force as a source term is discretized with PISO based finite volume method. Effects of the location of magnetic source and magnitude of current carrying from wire (1000, 2000, 3000, 4000 and 5000 amperes) are investigated on residence time and deposition level of drug on target tissue. Diameter and volume fraction of nanoparticles are 10 nm and 0.002, respectively. From the results, location of wire should be near and upstream the target tissue. Furthermore, by using this method deposition level of drug on target tissue can be increased by 7.5 times. Best drug delivery performance is seen for current magnitude of 2000 amperes.

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In this study, numerically investigated effect of magnetic heat sources (residual and hysteresis) that can be useful in hyperthermia and their effects on cancerous tissue. The governing equations of continuty, momentum, concentration, energy and Arrhenius tissue destruction equation in the form of couplings are defined, solved and investigated in the finite-element COMSOL software. For blood flow inside the cancerous capillary, non-newtonian and temperature dependent model is used. The geometric model is simulated in three dimensions, including the capillary and cancerous tissue. Thermophysical properties of blood and tissue are also temperature dependent. Results indicated that the residual heat source plays a major role in increasing the temperature of the blood and tissue and can be ignored the effect of hysteresis heat source. The residual heat source has an inverse relation to the particle size and is ineffective in the particle size above 100 nm but hysteresis heat source is directly related to the size of the nanoparticles, and for particles with a size of 150 nm, it will result in a 1 degree increase in temperature for the tissue. The increase in blood temperature for 25 nm magnetic nanoparticles with the residual heat source can lead to the most destruction in cancerous tissue. Also, the viscosity of blood has an inverse relation with the concentration of magnetic nanoparticles in the capillary wall and blood temperature.

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Milk, from its production to consumption, is exposed to a variety of microbial and chemical contaminants. Aflatoxin M1 (AFM1) is one of the most important contaminants in milk, which has always received attention due to its carcinogenic and destructive effects on the consumer. Accordingly, the rapid, sensitive, and cost-effective identification of AFM1 in milk is essential. In the present paper, an electrochemical aptasensor based on screen printed electrode (SPE) modified with magnetic nanoparticles (MNPs) and gold nanoparticles (AuNPs) was proposed to identify AFM1 in cow milk samples. SPE was activated by applying a potential within the range of -1.5 to +1 V versus the reference electrode at a scan rate of 200 mV/s for 5 continuous cycles in the 0.5 M sulfuric acid and 0.1 M potassium chloride solution. Changes of the electrode surface at different stages of preparation were assessed using cyclic voltammetry (CV) technique. Using CV in optimal conditions, it was found that the aptasensor presents a concentration range of 100-700 ng/l and a limit of detection (LOD) of 50 ng/l.  There was a linear relationship between changes of the current peak (∆I) and analyte concentration. This relationship follows the regression equation of ∆I=0.0209C+2.14 (R²=0.9897). Calculation of the relative standard deviation (RSD=3.2%) indicated the acceptable repeatability of the electrochemical aptasensor. The current peak was obtained to be 7.4% in the investigation of RSD reproducibility, indicating the good reproducibility of the electrochemical aptasensor. The obtained results showed that the aptasensor response after 8 days has only reduced by 7% compared to the first day, indicating the desirable stability of the aptasensor. The recovery percentage range for cow milk samples at concentrations of 100 and 200 ng/l was obtained to be 86.5 and 93%, respectively, showing the acceptable recovery percentage of the electrochemical aptasensor.