S. Ebrahimi Samani, S.m. Asghari , H. Naderimanesh , S. Hoseinkhani ,
Volume 9, Issue 2 (9-2018)
Abstract
Aims: Among different nanosystems, polymeric nanoparticles are highly regarded because of their potential to be used as drug carrier. poly(ethylene glycol)-block-lactide-glycolide (PEG-PLGA) is an amphiphilic copolymer that can be used to carry water-soluble drugs and drugs and molecules insoluble in water. PEG-PLGA polymeric nanoparticles can reduce renal filtration and drug toxicity; they are also biodegradable and biocompatible. The aim of this study was to optimize preparation of PEG-PLGA nanoparticles by solvent evaporation method.
Materials and Methods: In the present experimental study, PEG-PLGA nanoparticles with a diameter of 150nm and a zeta potential of -10 were prepared by solvent evaporation method. Then, the physicochemical properties of nanoparticles were carefully examined.
Findings: By increasing the polymer concentration and the percentage of polyvinyl alcohol, particle size increased. The production of nanoparticles with a concentration of 5mg/ml copolymer, a 2% w/v polyvinyl alcohol concentration, and in a 12:1 volume ratio showed the best size and superficial load. Morphologically, the nanoparticles were structurally similar and spherical. According to the FTIR spectrum, the peak in 2900-13000cm region was in accordance with the tensile bond C-H in CH3. A strong peak in 1760cm-1 was related to the tensile-CO that showed the copolymer formation.
Conclusion: The production of PEG-PLGA nanoparticles in a concentration of 5mg/ml copolymer, 2% w/v of polyvinyl alcohol concentration, and in a 12:1 volume ratio shows the best size and superficial load; also, the nanoparticles are structurally similar and spherical.
Volume 17, Issue 108 (1-2021)
Abstract
Much research has been done approaching replacing synthetic antioxidants with adverse nutritional effects. In this study, the antioxidant effect of microencapsulated sodium selenite in delaying oxidation of soybean oil was investigated. Microencapsulation of sodium-selenite was carried out, comprising the following combination: Arabic gum (25, 26, 27, 28, and 29%) and a corresponding amount of Farsi gum (corresponding to Arabic gum, respectively 1, 2, 3, 4, and 5%) using the solvent (ethanol with purity 96% ) evaporation method. The ratio of ethanol to the mix solution [combination gum + sodium selenite] was (4, 6, 8, 10, and 12). Finally, optimal formula1 (EE 94%, particle-size 64.9µm, Arabic gum 29%, Farsi gum 1%, and the ratio of ethanol to the mix solution 12 ) and the optimal formula2 (EE 84.4%, particle-size 74µm, Arabic gum 27%, Farsi gum 3%, and the ratio of ethanol to the mix solution 10) were selected. Consequently, the two selected optimal formulas (180.6PPM), the BHA(200PPM), and the un-microencapsulated sodium-selenite (8.6PPM) were added to antioxidant-free soybean oil and then were placed at the 55℃ for (0, 23, 46 days) equal to 20℃ (0, 180, 360 days) by shelf-life accelerator program. The oxidation indices were compared with soybean oil that did not contain any anti-oxidant. EE increased and particle size decreased with increasing Arabic gum levels and the ethanol to mix solution ratio. Encapsulated selenium, such as BHA, increased antioxidant activity and decreased soybean-oil oxidation indices. The effective and propositional treatments are presented in the following order respectively: blank (antioxidant-free) < un-microencapsulated sodium-selenite < BHA = Opt2 < Opt1.
