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Showing 2 results for Strontium
Shabnam Abedin Dargoush, Shiva Irani, Alirerza Naderi Sohi, Masoud Soleimani, Hana Hanaee-Ahvaz,
Volume 12, Issue 2 (1-2022)
Abstract
Graphene-based nanomaterials are being investigated for their biocompatibility and bioactivity, as well as their ability to improve osteogenic differentiation. In this research, the base material, reduced graphene oxide (rGO) sheets, were decorated with hydroxyapatite and strontium (rGO / HAp-Sr) to induce osteogenic differentiation in adipose-derived mesenchymal stem cells. Different techniques were used to determine the properties of the nanocomposite such as diffraction analysis techniques (XRD) and transmission electron microscopy (to evaluate the size and morphology of HAp-Sr on rGO plates), FT-IR (to analyze the nanocomposite functional group), Raman spectroscopy (to investigate possible disorders in nanocomposite structure and number of layers), induced dual plasma emission spectroscopy (to assess atomic concentration of Ca and Sr), zeta potential(electrical potential of the nanocomposite) and MTT (nanocomposite cytotoxicity assessment) were used. The ossification potential of the synthesized nanocomposite was investigated and confirmed using the calcium deposition test in dipose-derived mesenchymal stem cells. According to the obtained results, osteogenic differentiation induction is possible using synthesized nanocomposites without the need for chemical inducers.
Volume 22, Issue 3 (7-2019)
Abstract
Aims: Growing experiments show that biomaterials that have a bioactive glass (BG) indicate encouraging effects on bone tissue repair. Strontium-substituted BGs (BG/Sr) have been confirmed to improve bone formation while preventing bone resorption by osteoclasts.
Materials and Methods: This study aimed to evaluate the potential of strontium substitution on bioglass/gelatin (Gel) osteogenesis in critically sized rabbit calvarial defects. Defects were treated with Gel-BG or Gel-BG/Sr scaffolds and one defect was left unfilled as a control. Bone regeneration and mineralization process were evaluated by hematoxylin and eosin, Masson’s trichrome and Alizarin Red staining after 4 and 8 weeks post-implantation.
Findings: Based on the histological findings, newly formed bone area in scaffolds containing BG/Sr was greater than that without Sr after 8 weeks.
Conclusion: Our results specified that BG/Sr containing scaffolds could better increase bone regeneration than those without Sr and could be considered as a bone graft in bone tissue engineering.
