Volume 13, Issue 4 (2023)                   JMBS 2023, 13(4): 0-0 | Back to browse issues page

‎ 20.1001.1.23222115.1401.13.4.6.5

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Mortazavi S M R, Vaezi Z, Naderi-Manesh H. Synthesis of Cerosome nanoparticles and investigation of the stability and the release of loaded-Gallic acid as bioactive compound. JMBS 2023; 13 (4)
URL: http://biot.modares.ac.ir/article-22-60970-en.html
Synthesis of Cerosome nanoparticles and investigation of the stability and the release of loaded-Gallic acid as bioactive compound
Seyed Mohammad Reza Mortazavi1 , Zahra Vaezi2 , Hossein Naderi-Manesh * 3
1- Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
2- Department of Bioactive compounds, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, Iran
3- Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran , naderman@modares.ac.ir
Abstract:   (658 Views)
Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal tract. Despite numerous endeavors over the past few years, as well as an increase within the number of patients with the disease, there are currently limited medications available to manage intestinal inflammation. Designing a new biological treatment using natural bioactive medications with fewer side effects and more secure transmission than chemical compounds could be advantageous. In this study, a new strategy for the controlled release of Gallic acid as a bioactive polyphenol with anti-inflammatory impacts was proposed. This bioactive compound was loaded on a Cerosome nanocarrier and its stability was investigated. Cerosome-forming lipid (CFL) was synthesized through a two-step chemical reaction and then the Cerosomes were prepared by thin layer hydration by distinctive proportions of DPPC: CFL mole ratio. Cerosome with a mean diameter of 335 nm and zeta potential of -23 mV were homogeneous. The optimal formulation of the Cerosomal gallic acid system shows 34% loading and controlled release of the medication in gastrointestinal fluid environments. Structural stability was systematically evaluated by physicochemical characterization methods, and Cerasomes showed greater stability than liposomes and could be present longer in the bloodstream. These results indicate that Cerasomes can be a better medication delivery system for long-term storage and controllable release of gallic acid and have remarkable applications as carriers of intestinal inflammation drug delivery.
Keywords: Cerasome, Gallic acid, Sustained release, Inflammatory Bowel Disease, Drug delivery
Full-Text [PDF 1788 kb]   (187 Downloads)    
Article Type: Original Research | Subject: Nanotechnology
Received: 2022/04/18 | Accepted: 2022/06/27 | Published: 2023/11/19
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