Volume 10, Issue 4 (2019)                   JMBS 2019, 10(4): 565-572 | Back to browse issues page

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Abdolmajid E, Nemati F. Synthesis of Titanium Oxide Nanoparticles by Sol-Gel Method and Investigation of Physicochemical and Antibacterial Properties of Them on Prokaryotic and Eukaryotic Cells. JMBS 2019; 10 (4) :565-572
URL: http://biot.modares.ac.ir/article-22-25763-en.html
1- Biotechnology Department, New Sciences & Technologies Faculty, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran, Tehran Medical Sciences Branch, Islamic Azad University, Khaghani Street, Shatiati Street, Tehran, Iran. Postal Code: 1916893813 , elhamabdolmajid@iaups.ac.ir
2- Biotechnology Department, New Sciences & Technologies Faculty, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
Abstract:   (6779 Views)
Aims: The objective of this research was to develop a novel method for the synthesis of colloidal solutions of titanium dioxide nanoparticles with high stability and life span.
Materials & Methods: Based on mentioned points, the issue of this study is the synthesis of nanoparticles via chemical reduction process. The morphologies, compositions, and physicochemical properties of the prepared samples were characterized by TEM, XRD and DLS. Also, the cytotoxic effect of fabricated NPs against human white blood cells (WBCs) was investigated via MTT assay. In addition, antibacterial activity was investigated.
Findings: The results of this study indicate that the diameter of the synthesized nanoparticles is about 50nm and contains the anatase phase, in the range of 2θ from 25-80°C, and the hydrodynamic radius of nanoparticles is about 95.8±12.78nm and the zeta potential of nanoparticles is about -34.87±4.78mV. Also, the effect of toxicity of titanium dioxide nanoparticles on the white blood cell line showed that these nanoparticles cause the toxicity of cells at concentrations above 200μg/ml, but in lower concentrations, normal cells can survive. Also, these nanoparticles at the same low concentrations.
Conclusion: In conclusion, colloidal solutions with high stability were successfully synthesized, which, in addition to increasing the antibacterial properties due to diminished dimensions.
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Article Type: Original Research | Subject: Nanotechnology
Received: 2018/10/8 | Accepted: 2019/05/8 | Published: 2019/12/21

1. Woodrow Wilson Database. 2014. Nanotechnology consumer product inventory. http://www.nanotechproject.org/ cpi/about/analysis/. Accessed September. 24, 2015. [Link]
2. Al-Salim NI, Bagshaw SA, Bittar A, Kemmtt T, Mcquillan AJ, Mills AM, et al. Characterization and activity of sol - gel prepared TiO2 photo catalysts modified with Ca, Sr or Ba ion additives. J Mater Chem. 2010;10:2358-63. [Link] [DOI:10.1039/b004384m]
3. Venkatachalam N, Palanichamy M, Murugesan V. Sol-gel preparation and characterization of nanosize TiO2: Its photocatalytic performance. Mater Chem Phys. 2007;104(2-3):454-9. [Link] [DOI:10.1016/j.matchemphys.2007.04.003]
4. Priyadarshini E, Pradhan N, Panda PK, Mishra BK. Biogenic unmodified gold nanoparticles for selective and quantitative detection of cerium using UV-vis spectroscopy and photon correlation spectroscopy (DLS). Biosens Bioelectron. 2015;68:598-603. [Link] [DOI:10.1016/j.bios.2015.01.048]
5. Reddy KM, Manorama SV, Reddy AR. Bandgap studies on anatase titanium dioxide nanoparticles. Mater Chem Phys. 2003;78(1):239-45. [Link] [DOI:10.1016/S0254-0584(02)00343-7]
6. Ali SW, Rajendran S, Joshi M. Synthesis and characterization of chitosan and silver loaded chitosan nanoparticles for bioactive polyester. Carbohydr Polym. 2011;83(2):438-46. [Link] [DOI:10.1016/j.carbpol.2010.08.004]
7. Gupta SM, Tripathi M. A review of TiO2 nanoparticles. Chin Sci Bull. 2011;56(16):1639-57. [Link] [DOI:10.1007/s11434-011-4476-1]
8. Gan Q, Wang T, Cochrane C, McCarron P. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids Surf B Biointerfaces. 2005;44(2-3):65-73. [Link] [DOI:10.1016/j.colsurfb.2005.06.001]
9. Yien L, Zin NM, Sarwar A, Katas H. Antifungal activity of chitosan nanoparticles and correlation with their physical properties. Int J Biomater. 2012;2012:632698. [Link] [DOI:10.1155/2012/632698]
10. Wu MM, Chiou HY, Wang TW, Hsueh YM, Wang IH, Chen CJ, et al. Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan. Environ Health Perspect. 2001;109(10):1011-7. [Link] [DOI:10.1289/ehp.011091011]
11. Chen Z, Meng H, Xing G, Chen Ch, Zhao Y, Jia G, et al. Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett. 2006;163(2):109-20. [Link] [DOI:10.1016/j.toxlet.2005.10.003]
12. Revell PA. The biological effects of nanoparticles. Nanotechnol Percept. 2006;2:283 [Link]

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