Volume 12, Issue 4 (2021)                   JMBS 2021, 12(4): 147-165 | Back to browse issues page

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Shahsaman Z, Hasannia S. Bone morphogenetic proteins-2 and its medical applications. JMBS 2021; 12 (4) :147-165
URL: http://biot.modares.ac.ir/article-22-34936-en.html
1- Master in Biochemistry, Department of Biological Sciences Faculty, Tarbiat Modares University, Tehran, Iran
2- Associate Professor in Faculty of Biological Sciences, Tarbiat Modares University Tehran, Iran , hasannia@modares.ac.ir
Abstract:   (1806 Views)
Bone morphogenetic proteins (BMPs) are a subfamily of multifunctional superfamily transforming growth factor-beta (TGF-β), thus they have a lot of similarity in biosynthesis, structure, signaling and biological function with other members of the superfamily. They are involved in growth and differentiation of embryo to maintenance of adult cells. Among this family member, BMP-2 is a valuable protein that acts in different processes such as spinal fusions, articular cartilage damage therapy, tumor inhibition, gingivitis and dental treatment. The high importance of this protein and its low production rate in body caused several researches in the field of producing recombinant BMP-2 in different hosts. Recombinant production of the protein in bacterial host caused the decrease in production costs and therefore led to the common use of BMP-2 in treatment of various diseases. To date, positive effects of intact BMP-2 and its derivative peptides, in order to osteoinduction in fracture treatment and jaw bone regeneration for dental implantation, were considerable. Considering high clinical significance of BMP-2, there is a necessity for more investigations in relation to this protein.
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Article Type: Analytic Review | Subject: Pharmaceutical Biotechnology
Received: 2019/07/18 | Accepted: 2021/09/19 | Published: 2022/11/28

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