Volume 13, Issue 2 (2023)
JMBS 2023, 13(2): 71-79 |
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Salehi Siavashani M, Nakhai Sistani R, panahi A. Investigating the association between HLA-DQB1*03 with multiple sclerosis (MS) in Tehran. JMBS 2023; 13 (2) :71-79
URL: http://biot.modares.ac.ir/article-22-50404-en.html
URL: http://biot.modares.ac.ir/article-22-50404-en.html
1- University of kashan
2- University of kashan ,r.nakhaei@kashanu.ac.ir
3- University of Mohaghegh Ardabili
2- University of kashan ,
3- University of Mohaghegh Ardabili
Abstract: (1220 Views)
Aim: Multiple sclerosis is important in Iran because of its high prevalence and low age of onset. It exerts a large burden on affected people and the health care system. Studies have shown that the genetic content of humans has a critical role in MS. The histocompatibility loci which their products present the foreign antigenic peptides for detection by lymphocytes are of MS associated genetic elements. In this study, the association of HLA-DQB1*03 with MS was studied in Tehran, using a PCR-based system.
Methods: In this case-control study, a total of 367 blood samples were collected from 172 patients and 195 healthy people. Both groups were similar in age and gender. Blood DNA was extracted, and PCR technique was used to identify the presence of the allele.
Results: In this study, the HLA-DQB1*03 allele in men was significantly higher than that of women (p = 0.002). Also, the allele was less frequent in patients than in healthy subjects (53% versus 67%), and this difference is significant (p = 0.02).
Conclusions: The DQB1*03 allele is significantly lower in patients with MS than in healthy people, and this relationship is more pronounced in male subjects. Therefore, it seems that this allele plays a protective role against MS disease.
Methods: In this case-control study, a total of 367 blood samples were collected from 172 patients and 195 healthy people. Both groups were similar in age and gender. Blood DNA was extracted, and PCR technique was used to identify the presence of the allele.
Results: In this study, the HLA-DQB1*03 allele in men was significantly higher than that of women (p = 0.002). Also, the allele was less frequent in patients than in healthy subjects (53% versus 67%), and this difference is significant (p = 0.02).
Conclusions: The DQB1*03 allele is significantly lower in patients with MS than in healthy people, and this relationship is more pronounced in male subjects. Therefore, it seems that this allele plays a protective role against MS disease.
Article Type: Brief Communication |
Subject:
Molecular biotechnology
Received: 2021/02/22 | Accepted: 2021/11/30 | Published: 2023/07/10
Received: 2021/02/22 | Accepted: 2021/11/30 | Published: 2023/07/10
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