Volume 13, Issue 2 (2023)                   JMBS 2023, 13(2): 111-120 | Back to browse issues page

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Shirafkan F, Gharaghani S. Determination of intermediate proteins in the protein-protein interaction network considering common diseases in Moonlighting proteins. JMBS 2023; 13 (2) :111-120
URL: http://biot.modares.ac.ir/article-22-53609-en.html
1- Laboratory of Bioinformatics and Drug Design, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran,
2- Laboratory of Bioinformatics and Drug Design, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran,, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran , sgharaghani@yahoo.com
Abstract:   (839 Views)
Moonlight proteins are a subset of multifunctional proteins in which more than one independent or usually distinct function occurs in a single polypeptide chain. Analyzing the interactive networks of proteins in the cell makes it possible to understand how complex processes cause disease. With the help of systems biology, larger and more complex systems can be studied, and the molecular basis of several diseases can be considered. The proteins of the human organism that are moonlight are mostly involved in cancer, anemia, and neurodegeneration. In this work, we created a subnet according to the human PPI network, in which the nodes, the proteins that cause the three selected diseases, and the edges, are the connection of these proteins with each other. We measured the power of the indirect effects of non-disease mediators between the three disease groups and identified key disease-binding intermediate proteins. The results show the relationship between mediator role and centrality and between mediator role and functional properties of these proteins. We have shown that a protein that plays a key indirect mediator between two diseases is not necessarily a hub in the PPI network. Therefore, as hub proteins are considered, intermediate proteins should be considered. We have observed that the mediators between anemia and neurodegeneration diseases are functionally important in the cell. The mediator proteins suggested herein should be experimentally tested as hypothetical disease-related proteins.
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Article Type: Original Research | Subject: Bioinformatics
Received: 2021/06/26 | Accepted: 2022/03/6 | Published: 2023/07/10

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