ntroduction: Colorectal cancer (CRC) is one of the most important cancers and the second leading cause of cancer mortality in Iran. CRC is spread through genetic and epigenetic changes. Understanding the molecular pathways in these genetic and epigenetic changes can provide a clear perspective on cancer treatment.
Materials and Methods: This study was performed on 40 samples of intestinal tumor growths (polyps), 30 tumor samples and 40 normal tissues adjacent to the tumor. RNA and tissue DNA extraction, study of gene expression, miR-22, miR-194 LncRNA MINCR using Real time PCR was performed.
Results: In this study, the expression of MINCR LncRNA in tumor and polyp samples increased compared to the adjacent normal tissue and the expression of miR-194 miR-22 was decreased. Negative correlation coefficient was observed between miR-22, miR-194 and MINCR expression levels and also a significant relationship was observed between the expression of these lncRNAs and microRNAs.