Volume 15, Issue 2 (2024)                   JMBS 2024, 15(2): 0-0 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ehsandoost A, Tamjid E. 3D-printed polycaprolactone scaffold coated with silk fibroin and oxidized nanocellulose for wound dressing applications. JMBS 2024; 15 (2)
URL: http://biot.modares.ac.ir/article-22-73071-en.html
1- PhD student at Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University
2- Associate Professor of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Jalal-al-ahmad highway, Trabiat Modares University, P.O. Box 14115-175, Iran , tamjid@modares.ac.ir
Abstract:   (581 Views)
In recent years, significant efforts have been focused on advancements of novel biomaterials based on natural polymers and utilization of efficient methods such as skin tissue engineering for wound treatment. In this study, a 3D printed polycaprolactone (PCL) scaffold coated via immersion in a 1:4 blend of 40% silk fibroin from Bombyx mori cocoons and TEMPO-oxidized was developed. The pore size and the porosity were 180 µm and 85%, respectively. The results demonstrated an enhancement in exudate absorption (swelling and water uptake of 1342% and 80%, respectively), improvement in storage modulus (G’) from 500 to 4000 Pa, as well as viscoelasticity up to 60%, which all are favorable for wound dressing applications. Moreover, the wettability and biodegradability studies revealed an overall increase in contact angle and degradation rate of 19.9°±3, and 95%, respectively. Cell viability and migration studies on fibroblastic cells (L929) using MTT assay, DAPI/ Phalloidin staining, and scratch test showed over 90% viability up to 7 days and complete scratch repair within 24 hours. These findings show that 3D printed PCL scaffolds coated with silk fibroin and oxidized nanocellulose are promising for wound healing applications and might pave the way to natural polymer-based wound dressings.
 
Full-Text [PDF 1952 kb]   (419 Downloads)    
Article Type: Original Research | Subject: Nanotechnology
Received: 2023/12/23 | Accepted: 2024/03/10 | Published: 2024/06/24

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.