Volume 15, Issue 2 (2024)
JMBS 2024, 15(2): 0-0 |
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Ehsandoost A, Tamjid E. 3D-printed polycaprolactone scaffold coated with silk fibroin and oxidized nanocellulose for wound dressing applications. JMBS 2024; 15 (2)
URL: http://biot.modares.ac.ir/article-22-73071-en.html
URL: http://biot.modares.ac.ir/article-22-73071-en.html
1- PhD student at Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University
2- Associate Professor of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Jalal-al-ahmad highway, Trabiat Modares University, P.O. Box 14115-175, Iran ,tamjid@modares.ac.ir
2- Associate Professor of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Jalal-al-ahmad highway, Trabiat Modares University, P.O. Box 14115-175, Iran ,
Abstract: (610 Views)
In recent years, significant efforts have been focused on advancements of novel biomaterials based on natural polymers and utilization of efficient methods such as skin tissue engineering for wound treatment. In this study, a 3D printed polycaprolactone (PCL) scaffold coated via immersion in a 1:4 blend of 40% silk fibroin from Bombyx mori cocoons and TEMPO-oxidized was developed. The pore size and the porosity were 180 µm and 85%, respectively. The results demonstrated an enhancement in exudate absorption (swelling and water uptake of 1342% and 80%, respectively), improvement in storage modulus (G’) from 500 to 4000 Pa, as well as viscoelasticity up to 60%, which all are favorable for wound dressing applications. Moreover, the wettability and biodegradability studies revealed an overall increase in contact angle and degradation rate of 19.9°±3, and 95%, respectively. Cell viability and migration studies on fibroblastic cells (L929) using MTT assay, DAPI/ Phalloidin staining, and scratch test showed over 90% viability up to 7 days and complete scratch repair within 24 hours. These findings show that 3D printed PCL scaffolds coated with silk fibroin and oxidized nanocellulose are promising for wound healing applications and might pave the way to natural polymer-based wound dressings.
Keywords: 3D printing, Polycaprolactone, Silk Fibroin, Oxidized Nanocellulose, Wound Dressing, Viscoelasticity, Cell Viability, Cell Migration
Article Type: Original Research |
Subject:
Nanotechnology
Received: 2023/12/23 | Accepted: 2024/03/10 | Published: 2024/06/24
Received: 2023/12/23 | Accepted: 2024/03/10 | Published: 2024/06/24
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