Volume 15, Issue 3 (2024)
JMBS 2024, 15(3): 0-0 |
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Abdi F, Zarebkohan A, بانی ف, Jafarirad S. Synthesis and Characterization of Sm/Fe2O3 Nanocomposite and Investigation of Protein Corona Formation and Its Effects on Uptake and Cytotoxicity of the Nanocomposite. JMBS 2024; 15 (3)
URL: http://biot.modares.ac.ir/article-22-74361-en.html
URL: http://biot.modares.ac.ir/article-22-74361-en.html
1- University of Tabriz
2- Tabriz University of Medical Sciences
3- Tabriz University of Medical Sciences ,bani.farhad56@gmail.com
2- Tabriz University of Medical Sciences
3- Tabriz University of Medical Sciences ,
Abstract: (396 Views)
Iron oxide nanocomposites with lanthanides, due to their unique magnetic properties and biocompatibility, are recognized as attractive agents for the detection and treatment of cancerous tumors. Therefore, understanding the interaction of these nanocomposites with biological systems is important for their efficient design. In this study, samarium-doped magnetite iron oxide nanocomposite was synthesized chemically based on polyethylene glycol and triethanolamine. The nanocomposite w::::::::as char::::::::acterized using XRD, SEM, EDX, and DLS techniques. The crystal size of the nanocomposite was calculated to be approximately 12 nanometers using XRD. SEM image showed the synthetic nanocomposite as an agglomeration of fine particles with a spherical morphology. Subsequently, by incubating the nanocomposite in human blood plasma, the formation of a protein complex called corona protein on the surface of nanoparticles when exposed to biological systems was investigated and confirmed by gel electrophoresis. Cellular uptake results in the interaction of nanoparticles with cells showed that incubating the nanocomposite in human blood plasma led to a decrease in nanoparticle uptake in MDA-MB231 cancer cells and an increase in uptake in RAW 264.7 macrophages, indicating the binding of blood opsonin proteins on the nanoparticle surface. Furthermore, the results indicated that the formation of corona protein had no significant effect on the cellular toxicity of nanoparticles on MDA-MB231 cells at different nanoparticle concentrations up to 200 micrograms per milliliter, and no significant toxicity was reported.
Article Type: Original Research |
Subject:
Nanotechnology
Received: 2024/03/18 | Accepted: 2024/07/17 | Published: 2024/10/6
Received: 2024/03/18 | Accepted: 2024/07/17 | Published: 2024/10/6
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