Modares Journal of Biotechnology

Prediction of flexibility in proteins based on sequence of amino acids

Authors

Seyed Shahriar Arab 1
Mehdi Sadeghi 2
Changiz ESlahchi 3
Hamid Pezeshk 4

1 1. School of Computer Science, Institute for Studies in Theoretical Physics and Mathematics, Tehran, P. O. Box 19395-5746

2 National Institute of Genetic Engineering and Biotechnology, Tehran-Karaj Highway, Tehran, P.O. Box 14155-6343

3 Department of Mathematical Sciences, Shahid Beheshti University, Tehran, P.O. Box:1983963113

4 Center of Excellence in Biomathematics, School of Mathematics, Statistics and Computer Sciences, University College of Science, University of Tehran, Tehran, P.O. Box: 14165-6455

Abstract
We present a method to predict the flexible and rigid regions based on sequence. We use the free energy of two consequent amino acids to define a factor for distinguishing flexible regions from the rigid ones. Using statistical analysis of this free energy, we assign a normalized number between zero to one hundred which we call it flexibility number. Taking the effects of up to four neighbors of an amino acid, into account, resulted in an efficient prediction of flexible and rigid regions of a protein.

Keywords

conformational flexibility
protein function prediction
flexible/rigid region prediction
protein structure prediction

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