Escherichia Coli: the most useful host for production of recombinant proteins

Bakhtiari, Nahid; Vaez, Mohsen

Escherichia Coli: the most useful host for production of recombinant proteins

Document Type : Analytic Review

Authors

Nahid Bakhtiari ¹

Mohsen Vaez ²

¹ Biotechnology department, Iranian research organization for science and technology

² biotechnology department, Iranian Research organization for science and technology

Abstract

One of the most important hosts used for production of recombinant proteins is Escherichia Coli. For example, the most therapeutic proteins approved by FDA are produced in Escherichia Coli. Comprehensive knowledge about biologic nature of Escherichia Coli had made this microorganism to a favorable factory for production of recombinant proteins. Accessibility of this information have led to rational manipulation for changing of this small factory to intelligent system can make different recombinant proteins easier. So that, many engineered and useful strains were obtained from wild type and parental strains can produce high amount of diverse and stable recombinant proteins in lab and industrial scale. In this review, we will present some of these strains that are more widely used.

Keywords

Escherichia coli

Recombinant Protein

Host

Subjects

Molecular biotechnology

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