Volume 13, Issue 3 (2023)
JMBS 2023, 13(3): 93-112 |
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Amini Toolarood Payin F, Salarian R, hosseini S M, Shahavi M H, ebadi T. Synthesis of thiolated nanochitosan as a carrier of biperidine using two cross linkers Tripolyphosphate (TPP) and Genipine and evaluation of their release and toxicity. JMBS 2023; 13 (3) :93-112
URL: http://biot.modares.ac.ir/article-22-52549-en.html
URL: http://biot.modares.ac.ir/article-22-52549-en.html
Fakhimeh Amini Toolarood Payin1 
, Reza Salarian2 , Seyed mehdi Hosseini * 3, Mohammad Hasan Shahavi4 , Tahmine Ebadi5
, Reza Salarian2 , Seyed mehdi Hosseini * 3, Mohammad Hasan Shahavi4 , Tahmine Ebadi5
1- graduated master's degree in biomedical engineering from Maziar University, Royan, IRAN
2- department of biomedical engineering, Maziar University, Royan, IRAN
3- department of medicinal plants, Amol University of Special Modern Technologies, Amol, IRAN ,hosseini.sayedmehdi@gmail.com
4- Assistant professor,Faculty of Modern Technologies Engineering, Amol University of Special Modern Technologies, Amol, Iran
5- faculty of chemical engineering, babol noshirvani university of technology, Babol, P.O. Box 47148-73113
2- department of biomedical engineering, Maziar University, Royan, IRAN
3- department of medicinal plants, Amol University of Special Modern Technologies, Amol, IRAN ,
4- Assistant professor,Faculty of Modern Technologies Engineering, Amol University of Special Modern Technologies, Amol, Iran
5- faculty of chemical engineering, babol noshirvani university of technology, Babol, P.O. Box 47148-73113
Abstract: (1351 Views)
Background: Modern science in drug delivery systems has long been paid to effectively design drug delivery systems, to reduce side effects, increasing bioavailability, targeted drug delivery, and passing through blood-brain barriers. Nanoparticles are very important as carriers because they carry different types of drugs to different parts of the body at the right time. Method: In the present study, thiolated nano chitosan loaded with Biperiden was synthesized by ion gel method using two types of crosslinkers (tripolyphosphate and genipin) and their efficiency was investigated. Results: FTIR analysis confirmed the successful synthesis of various stages of thiolated nano chitosan loaded with Biperiden by both crosslinkers. SEM images showed that as-synthesized nano-carriers have a nanorod structure and nanocarriers crosslinked by genipin had a more regular structure with a size of about 150 nm than nanocarrier crosslinked by TPP with a size of approximately 200 nm. In vitro drug release and cytotoxicity studies showed nano-carriers crosslinked by genipin have had a higher release and less cytotoxicity than nano-carriers crosslinked by TPP. Conclusion: Considering the lower toxicity and delayed release of nanoparticles synthesized with genipine than nanocarriers synthesized with TPP, the use of this nanocarrier increases the bioavailability of the drug and can be used as a suitable drug delivery system.
Article Type: Original Research |
Subject:
Nanotechnology
Received: 2021/05/15 | Accepted: 2022/04/26 | Published: 2023/10/22
Received: 2021/05/15 | Accepted: 2022/04/26 | Published: 2023/10/22
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