Volume 11, Issue 1 (2020)
JMBS 2020, 11(1): 37-43 |
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ranjbar S, Khajeh K, Mirnajafi-Zadeh J, Dabirmanesh B, Khodaverdian S. Evaluation of changes expression of D1, mGluR1 and CD38 genes after electrical kindling and treatment with low-frequency stimulation in rat. JMBS 2020; 11 (1) :37-43
URL: http://biot.modares.ac.ir/article-22-32002-en.html
URL: http://biot.modares.ac.ir/article-22-32002-en.html
Samira Ranjbar1 
, Khosro Khajeh * 2, Javad Mirnajafi-Zadeh1 , Bahareh Dabirmanesh1 , Shima Khodaverdian1
, Khosro Khajeh * 2, Javad Mirnajafi-Zadeh1 , Bahareh Dabirmanesh1 , Shima Khodaverdian1
1- Tarbiat Modares University
2- Tarbiat Modares University, Tehran, Jalal AleAhmad, Nasr, Tarbiat Modares University, Postal code:14115-154 ,Khajeh_k@yahoo.com
2- Tarbiat Modares University, Tehran, Jalal AleAhmad, Nasr, Tarbiat Modares University, Postal code:14115-154 ,
Abstract: (4949 Views)
Electrical Kindling is one of the most popular epileptic model techniques that cause seizures such as temporal lobe epilepsy. So far, various therapies have been used to treatment of epilepsy. Among these treatments, low-frequency stimulation (LFS) has been widely considered for improving effect on drug-resistant epilepsy, but its mechanism is not well understood. Since calcium entering to the cytoplasm and increasing its concentration is one of the reasons for seizure, metabotropic glutamate receptor (mGluR1), dopamine receptor (D1) and ADPR cyclase (CD38), which increased calcium in the cytoplasm from different pathways, were selected. With this aim that by examining the change in the expression of these genes, we help to clarify the LFS improvement effect. In this study, the hippocampus of rats was used and the changes in genes expression were investigated using real-time PCR technique. The results showed that the expression of all selected genes increased significantly after kindling and then after the LFS the expression of all was returned to sham value. Hence, one of the ways in which LFS interferes may be related to the pathway for calcium entering to the cytoplasm.
Article Type: Original Research |
Subject:
Molecular biotechnology
Received: 2019/04/15 | Accepted: 2019/07/24 | Published: 2020/06/6
Received: 2019/04/15 | Accepted: 2019/07/24 | Published: 2020/06/6
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