Volume 13, Issue 1 (2022)
JMBS 2022, 13(1): 157-171 |
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kordi M, ghahremani S. Aptamer, applications and its design in silico method. JMBS 2022; 13 (1) :157-171
URL: http://biot.modares.ac.ir/article-22-55312-en.html
URL: http://biot.modares.ac.ir/article-22-55312-en.html
1- Department of Biotechnology, Faculty of Life Sciences & Biotechnology, Shahid Beheshti University, Tehran, Iran. Ma_kordi@sbu.ac.ir , mkordi90@yahoo.com
2- Department of Biotechnology, Faculty of Life Sciences & Biotechnology, Shahid Beheshti University, Tehran, Iran.
2- Department of Biotechnology, Faculty of Life Sciences & Biotechnology, Shahid Beheshti University, Tehran, Iran.
Abstract: (3664 Views)
Abstract:
Aptamers are single-stranded sequences of RNA, DNA, or highly specific proteins that tend to bind to a wide range of target molecules. Aptamers are widely used in various fields, especially medicine and diagnostics, and are similar in their application to antibodies. There are many benefits to using aptamer instead of antibodies, such as low cost, longer life, increased tissue permeability, and more. There are several methods for producing aptamer that in silico methods can shorten and simplify the steps of aptamer production. With aptamer modeling, a set of in silico methods such as modeling, docking, and molecular dynamics can be used to screen for the best aptamer sequence. In this article, a review of the types of aptamers, their structure and design methods in silico is briefly stated.
Keywords: Aptamer, DNA, RNA, Protein, insilico
Keywords: Aptamer, DNA, RNA, Protein, insilico
Aptamers are single-stranded sequences of RNA, DNA, or highly specific proteins that tend to bind to a wide range of target molecules. Aptamers are widely used in various fields, especially medicine and diagnostics, and are similar in their application to antibodies. There are many benefits to using aptamer instead of antibodies, such as low cost, longer life, increased tissue permeability, and more. There are several methods for producing aptamer that in silico methods can shorten and simplify the steps of aptamer production. With aptamer modeling, a set of in silico methods such as modeling, docking, and molecular dynamics can be used to screen for the best aptamer sequence. In this article, a review of the types of aptamers, their structure and design methods in silico is briefly stated.
Keywords: Aptamer, DNA, RNA, Protein, insilico
Keywords: Aptamer, DNA, RNA, Protein, insilico
Article Type: Systematic Review |
Subject:
Bioinformatics
Received: 2021/09/1 | Accepted: 2022/02/5 | Published: 2023/01/4
Received: 2021/09/1 | Accepted: 2022/02/5 | Published: 2023/01/4
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