Electrospinning polyurethane nanocomposite reinforced by graphene oxide, selenium nanoparticles and henna extract for wound dressing applications

Sepanloo, Shahab; Jalaly, Maisam; Mirzapour, Aboulfazl; Parsay, Ali

Electrospinning polyurethane nanocomposite reinforced by graphene oxide, selenium nanoparticles and henna extract for wound dressing applications

Document Type : Original Research

Authors

Shahab Sepanloo ¹

Maisam Jalaly ¹

Aboulfazl Mirzapour ²

Ali Parsay ¹

¹ Iran University of Science and Technology

² Tarbiat Modarres University

Abstract

It is inevitable to replace the tissues and organs that were disrupted due to trauma or various diseases. One of the methods that can help to speed up the regeneration of wounds is to improve the technology of wound dressings. In the current research, by using the properties of polyurethane nanofibers and improving their properties with additives including graphene oxide, selenium nanoparticles, and henna plant extract, it was aimed to improve the performance of wound dressings. After finding the optimal concentration for the electrospinning machine, DMSO solution containing 12 wt.% polyurethane was used to produce wound dressing nanofibers. The images from scanning electron microscope (SEM) confirmed the production of uniform scaffolds composed of polyurethane nanofibers. Antibacterial properties and mechanical properties of the fabric were studied to check the performance of the manufactured fabric as a wound dressing. For the PU-GO-Se-Henna composite sample, the antibacterial activity against two bacteria, S.aureus and E.coli, was 3.26 and 2.85, respectively, which indicates the very attractive antibacterial properties. This sample reached a tensile strength of 92 MPa in the tensile test, which showed a 104% increase in strength compared to the pure polyurethane sample.

Keywords

Wound Dressing

Nanocomposite

Polyurethane

Electrospinning

Bacteria

Subjects

Nanotechnology

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