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Serasome-antibody: a smart nanocarrier for diagnostic and delivery purposes
Maryam Vesal1 , Zahra Vaezi2 , عبداله اله‌وردی * 3, Hossein Naderi-Manesh4
1- Tarbiat Modares University, Faculty of Biological Sciences, Department of Biophysics, Tehran - Iran
2- Tarbiat Modares University, Faculty of Interdecipnary Technologies, Tehran - Iran
3- Tarbiat Modares University, Faculty of Biological Sciences, Dept. of Biophysics, Tehran- Iran , a-allahverdi@modares.ac.ir
4- Tarbiat Modares University, Faculty of Biological Sciences, Department of Biophysics. Tehran - Iran
Abstract:   (7 Views)
In recent years, targeted drug delivery systems have emerged as a promising approach to increase the efficacy and minimize side effects of therapeutic agents. Cerasomes are a special type of liposomes with covalent siloxane networks on the surface that provide exceptional morphological stability while retaining all the beneficial properties of liposomes. Cerosomes provide a unique platform for drug encapsulation and delivery due to their biocompatibility, stability, controllable release, and long-term storage. In this research, an attempt has been made to engineer the surface of cerosomes to increase the selectivity and efficiency of drug delivery. In such a way that the Herceptin antibody is placed on the surface of the serosa and allows the precise targeting of HER2+ cells. Then, the physicochemical characteristics of antibody-functionalized cerosomes, including size and surface charge 229±15.6 nm and 13.5±1.2 mV were respectively obtained. The results of IR and fluorescence spectrum showed that the antibody was successfully attached to the surface of cerasome with a binding efficiency of 64%. These results prove the basic mechanisms governing the synthesis of immunocerasomes and provide a valuable approach for future developments in targeted drug delivery systems.
 
Keywords: cerasome, antibody, targeted drug delivery, breast cancer
     
Article Type: Original Research | Subject: Pharmaceutical Biotechnology
Received: 2024/05/26 | Accepted: 2024/08/24
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